Results 11 to 20 of about 464,022 (216)
Rational and combinatorial tailoring of bioactive cyclic dipeptides [PDF]
Frontiers in Microbiology, 2015 Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They display a broad variety of biological and pharmacological activities and have long been recognized as privileged structures with the ability to bind to a wide ...
Tobias Wolfgang Giessen +2 more
doaj +7 more sources
The tRNA-Dependent Biosynthesis of Modified Cyclic Dipeptides [PDF]
International Journal of Molecular Sciences, 2014 In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnover and secondary metabolite assembly.
Tobias W Giessen, Mohamed A Marahiel
exaly +5 more sources
CONFORMATIONAL STUDIES ON CYCLIC DIPEPTIDES*
International Journal of Peptide and Protein Research, 1977 An analysis of 11 crystal structures of cyclic dipeptides so far reported in the literature is made, with main reference to the internal parameters of these molecules. Preferred conformations of the side chains of cyclic dipeptides with different α‐amino acid residues have been studied by classical energy calculations. The possible conformations of the
Ramani, R +2 more
core +4 more sources
The Biological Activity of Selected Cyclic Dipeptides
Journal of Pharmacy and Pharmacology, 1998 Abstract Cyclic dipeptides are widely used as models for larger peptides because of their simplicity and limited conformational freedom. Some cyclic dipeptides have been shown to be antiviral, antibiotic and anti-tumour. The aim of this study was to determine the biological activity of four cyclic dipeptides synthesized in this ...
P J, Milne +4 more
openaire +3 more sources
A minimalistic hydrolase based on co-assembled cyclic dipeptides [PDF]
Organic & Biomolecular Chemistry, 2019 Cyclic dipeptides based on proteinogenic amino acids form higher aggregates in water with an enzyme-like activity. Are they relevant for abiogenesis?
Alexander Kleinsmann, Boris Nachtsheim
openaire +3 more sources
Identification of Cyclic Dipeptides and a New Compound (6-(5-Hydroxy-6-methylheptyl)-5,6-dihydro-2H-pyran-2-one) Produced by Streptomyces fungicidicus against Alternaria solani [PDF]
Molecules, 2022 As an important microbial resource, Actinomycetes, especially Streptomyces, have important application values in medicine and biotechnology. Streptomyces fungicidicus SYH3 was isolated from soil samples in tomato-growing areas and showed good inhibitory ...
He Liu +11 more
doaj +2 more sources
Food Hydrocolloids for HealthIn this study, we analyzed the absorption of linear and cyclic dipeptides containing Gly, Pro, Ala, and Val by human blood following the ingestion of elastin hydrolysate.
Yu Iwasaki +4 more
doaj +2 more sources
Cyclic dipeptides: from bugs to brain
Trends in Molecular Medicine, 2014 Cyclic dipeptides (CDPs) are a group of hormone-like molecules that are evolutionarily conserved from bacteria to humans. In bacteria, CDPs are used in quorum sensing (QS) to communicate information about population size and to regulate a behavioural switch from symbiosis with their host to virulence.
BELLEZZA, ILARIA +2 more
openaire +3 more sources
Untargeted metabolomics identifies a bacterial cyclic dipeptide that induces resistance to a rust fungus of beans [PDF]
Scientific ReportsGenistein and daidzein are isoflavonoid phytoalexins that increase rapidly during bean hypersensitive immunity to Pseudomonas savastanoi pv. phaseolicola. To understand how genistein and daidzein affect P. savastanoi pv.
Bret Cooper +2 more
doaj +2 more sources
Cyclic Dipeptides in the Induction of Maturation for Cancer Therapy
Journal of Pharmacy and Pharmacology, 2000 Abstract Studies have suggested a possible form of therapy based on the use of maturation-inducing compounds to induce differentiation of neoplastic cells and stimulate faster recovery of the normal cell population. The study of the effects of nine cyclic dipeptides on biochemical markers of differentiation implicated their potential to ...
Graz, CJM +5 more
openaire +4 more sources