Results 101 to 110 of about 8,341 (207)

Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances

Marine Drugs
Five new metabolites, including three cyclic dipeptide derivatives (1–3) and two new polyketides (10–11), together with nine known ones (4–9 and 12–15), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431.
Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xuefeng Zhou   +7 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, EarlyView.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

Evaluating the In Vitro Digestibility of Black Soldier Fly (Hermetia illucens L.) Larvae as Potential Feed Ingredient in Dairy Cattle Silage‐Based Diets: A Focus on Proteins

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Dietary protein has a substantial economic impact on cattle feed, and it is also a critical component for animal growth and productivity. Several environmental issues related to soybeans have led to an increased interest in novel protein sources, such as insects.
Maria Giulia Bonomini, Marica Simoni, Matteo Profeti, Federico Righi, Augusta Caligiani   +4 more
wiley   +1 more source

Cyclic Dipeptide Cyclo(l-Phe-l-Pro) Derived from Beauveria bassiana Exhibits Stronger Antifungal Activity than Beauvericin Against Fusarium oxysporum

Agriculture
Fusarium oxysporum f. sp. lycopersici (Fol) is a destructive soil-borne pathogen responsible for major global losses in tomato production, within a context of increasingly constrained fungicide use in intensive farming systems.
Marta Ranesi, Martina Sinno, Alessia Staropoli, Maria Michela Salvatore, Stefania Vitale, Anna Andolfi, Sheridan Lois Woo, David Turrà, Francesco Vinale   +8 more
doaj   +1 more source

A cyclic dipeptide from the Chilean hazelnut cotyledons (Gevuina avellana Mol., Proteaceae). [PDF]

Sci Rep, 2020
Schmeda-Hirschmann G, de Andrade JP, Jiménez-Aspee F, Mieres-Castro D.   +3 more
europepmc   +1 more source

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation

Immunology, Volume 179, Issue 1, Page 101-117, September 2026.
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai, Paleerath Peerapen, Visith Thongboonkerd   +2 more
wiley   +1 more source

Co-solvent polarity tuned thermochromic nanotubes of cyclic dipeptide-polydiacetylene supramolecular system. [PDF]

RSC Adv, 2020
Khazi MI, Balachandra C, Shin G, Jang GH, Govindaraju T, Kim JM.   +5 more
europepmc   +1 more source

NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana

New Phytologist, Volume 251, Issue 5, Page 2741-2752, September 2026.
Proteomic analysis revealed that receptor kinases (red) accumulate higher in rd21 knockout Nicotiana benthamiana plants. Summary RD21‐like proteases are papain‐like cysteine proteases with a C‐terminal granulin domain that are abundant and ubiquitous in angiosperms and have often been implicated in immunity.
Alice Godson, Lauren Eddie, Mariana Schuster, Kaijie Zheng, Reka Toth, Yuge Li, Tianrun Li, Jie Huang, Farnusch Kaschani, Philippe V. Jutras, Jiorgos Kourelis, Markus Kaiser, Tolga Bozkurt, Renier A. L. Van der Hoorn   +13 more
wiley   +1 more source