Results 1 to 10 of about 3,309 (181)

The Chemistry and Pharmacology of the Alkaloid Barettin and Its Analogues from the Marine Sponge Geodia barretti: Progress and Perspectives [PDF]

Marine Drugs
The cold-water siliceous sponge Geodia barretti, largely present in the North Atlantic Ocean, notably around Scandinavian costs, plays important roles in carbon and silicon cycling in the deep-sea.
Christian Bailly
doaj   +2 more sources

Four New Pairs of MetO-Containing Diketopiperazine Enantiomers: Isolation, Synthesis and Potential Anti-Parkinson’s Disease Activity [PDF]

Marine Drugs
Four new methionine sulfoxide-containing diketopiperazines, (+)-dysidmetsulfoxide A [(+)-1], (+)-dysidmetsulfoxide B [(+)-2], (+)-dysidmetsulfoxide C [(+)-3] and (−)-dysidmetsulfoxide C [(−)-3], were isolated from the South China Sea sponge Dysidea sp ...
Yu Lei, Zhenyu Yang, Daichun Li, Xiaojian Liao, Chamari Hettiarachchi, Bingxin Zhao, Shihai Xu   +6 more
doaj   +2 more sources

The Novel Diketopiperazine Derivative, Compound 5-3, Selectively Inhibited the Proliferation of FLT3-ITD Mutant Acute Myeloid Leukemia (AML) Cells [PDF]

Marine Drugs
The internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) is associated with high recurrence and mortality rates in acute myeloid leukemia (AML), making it a critical target for anti-AML therapies.
Shijie Bi, Yating Cao, Shiyuan Fang, Yanyan Chu, Zixuan Zhang, Meng Li, Rilei Yu, Jinbo Yang, Yu Tang, Peiju Qiu   +9 more
doaj   +2 more sources

A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

Molecules, 2014
A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum.
Xuan Liu, Jintian Tang, Xianwei Zou
exaly   +3 more sources

2,5-Diketopiperazine Derivatives as Potential Anti-Influenza (H5N2) Agents: Synthesis, Biological Evaluation, and Molecular Docking Study

Molecules, 2022
2,5-Diketopiperazine derivatives, consisting of benzylidene and alkylidene substituents at 3 and 6 positions, have been considered as a core structure for their antiviral activities.
Chanakan Winyakul, Weerachai Phutdhawong, Poomipat Tamdee, Jitnapa Sirirak, Thongchai Taechowisan, Waya S. Phutdhawong   +5 more
doaj   +1 more source

Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

Nature Communications, 2023
The 2,5-diketopiperazines are a prominent class of bioactive molecules. The nocardioazines are actinomycete natural products that feature a pyrroloindoline diketopiperazine scaffold composed of two D-tryptophan residues functionalized by N- and C ...
Garrett Deletti, Sajan D. Green, Caleb Weber, Kristen N. Patterson, Swapnil S. Joshi, Tushar M. Khopade, Mathew Coban, James Veek-Wilson, Thomas R. Caulfield, Rajesh Viswanathan, Amy L. Lane   +10 more
doaj   +1 more source

Total Synthesis of the Four Stereoisomers of Cyclo(l-Trp-l-Arg) Raises Uncertainty of the Structures of the Natural Products and Invalidates Their Promising Antimicrobial Activities

Molecules, 2022
New therapeutic options to combat the growing incidence of antimicrobial resistance are urgently needed. A 2015 publication reported the isolation and biological evaluation of two diketopiperazine natural products, cyclo(l-Trp-l-Arg) (CDP 2) and cyclo(d ...
Dan Chen, Daniel J. Park, Melissa M. Cadelis, Hana Douafer, Marie Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp   +6 more
doaj   +1 more source

Analysis of the isomerization of diketopiperazine consisting of proline and aromatic amino acid residues using nuclear magnetic resonance

Analytical Science Advances, 2022
Under different concentrations of the base potassium deuteroxide KOD, the progress of reactions, such as enolization, D‐substitution, isomerization, and conformational changes of diketopiperazine cyclo(L‐Pro‐L‐Xxx) and cyclo(D‐Pro‐L‐Xxx) (Xxx = Phe, Tyr)
Takashi Ishizu, Popuri Sato, Shiori Tsuyama, Ryosuke Nagao, Kanae Fujiki, Amia Yamaji   +5 more
doaj   +1 more source

(E)-N-(3-(5-(3-Acetamidopropyl)-3,6-dioxopiperazin-2-yl)propyl)-5-hydroxy-3-methylpent-2-enamide

Molbank, 2023
The Atacama Desert is an unexplored habitat with interesting possibilities for natural product chemistry due to the adaptations employed by microorganisms to survive the extreme salinity and high UV radiation present.
Gagan Preet, Rishi Vachaspathy Astakala, Joy Ebenezer Rajakulendran, Emmanuel T. Oluwabusola, Rainer Ebel, Marcel Jaspars   +5 more
doaj   +1 more source

Integrating Molecular Networking and ¹H NMR Spectroscopy for Isolation of Bioactive Metabolites from the Persian Gulf Sponge Axinella sinoxea

Marine Drugs, 2020
The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely ...
Reza Mohsenian Kouchaksaraee, Mahdi Moridi Farimani, Fengjie Li, Melika Nazemi, Deniz Tasdemir   +4 more
doaj   +1 more source