Results 21 to 30 of about 3,309 (181)

Double the Chemistry, Double the Fun: Structural Diversity and Biological Activity of Marine-Derived Diketopiperazine Dimers

open access: yesMarine Drugs, 2019
While several marine natural products bearing the 2,5-diketopiperazine ring have been reported to date, the unique chemistry of dimeric frameworks appears to remain neglected.
Nelson G. M. Gomes   +3 more
doaj   +1 more source

Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans

open access: yesMolecules, 2019
The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase, and plays an important role in the pathogenesis of microorganisms during infection.
Heegyu Kim   +3 more
doaj   +1 more source

Diketopiperazine Alkaloids and Bisabolene Sesquiterpenoids from Aspergillus versicolor AS-212, an Endozoic Fungus Associated with Deep-Sea Coral of Magellan Seamounts

open access: yesMarine Drugs, 2023
Two new quinazolinone diketopiperazine alkaloids, including versicomide E (2) and cottoquinazoline H (4), together with ten known compounds (1, 3, and 5–12) were isolated and identified from Aspergillus versicolor AS-212, an endozoic fungus associated ...
Yu-Liang Dong   +5 more
doaj   +1 more source

Taxonogenomic Analysis of Marine-Derived Streptomyces sp. N11-50 and the Profile of NRPS and PKS Gene Clusters

open access: yesHydrobiology, 2023
Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin and cyclo(Phe-Leu).
Hisayuki Komaki   +2 more
doaj   +1 more source

A mechanochemical approach to access the proline–proline diketopiperazine framework

open access: yesBeilstein Journal of Organic Chemistry, 2017
Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptides ...
Nicolas Pétry   +9 more
doaj   +1 more source

Electron Transfer-Induced Coupling of Haloarenes to Styrenes and 1,1-Diphenylethenes Triggered by Diketopiperazines and Potassium tert-Butoxide

open access: yesMolecules, 2015
The coupling of haloarenes to styrenes and 1,1-diarylethenes has been achieved with potassium tert-butoxide in the presence of N,N'-dialkyldiketopiperazines.
Eswararao Doni   +2 more
doaj   +1 more source

Pseudomonas aeruginosa inhibits quorum-sensing mechanisms of soft rot pathogen Lelliottia amnigena RCE to regulate its virulence factors and biofilm formation

open access: yesFrontiers in Microbiology, 2022
The quorum-sensing (QS) cascade is responsible for the colonization and phenotypic behavior of the pathogenic organism and the regulation of diverse signal molecules.
Chintan Kapadia   +8 more
doaj   +1 more source

Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators

open access: yesMolecules, 2017
It has been proven that specific isoforms of human carbonic anhydrase (hCA) are able to fine-tune physiological pathways connected to signal processing, and that decreased CAs expression negatively influences cognition, leading to mental retardation ...
Adriano Mollica   +6 more
doaj   +1 more source

A Practical Sulfenylation of 2,5‐Diketopiperazines [PDF]

open access: yesAngewandte Chemie, 2011
Sulfurs in action A practical and simple method for the introduction of sulfur atoms into 2,5-diketopiperazines (I) under mild conditions has been developed leading to more or less complex epidithiodiketopiperazines (II) and bis-methylthiodiketopiperazines (III).
K C, Nicolaou   +3 more
openaire   +2 more sources

A Convenient Strategy to Access Diverse Libraries of Amphiphilic Compounds Based on Glycopeptoids

open access: yesChirality, Volume 38, Issue 7, July 2026.
A synthetic platform based on a convergent synthetic strategy enables rapid access to a diverse amphiphilic glycopeptoids library. These modular systems exhibit self‐assembly into nanoscale aggregates, highlighting their potential as customizable platforms for drug delivery, biomimetic materials, and membrane protein stabilization.
Ludovica Dei   +9 more
wiley   +1 more source

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