Results 31 to 40 of about 5,442 (212)
A Practical Sulfenylation of 2,5‐Diketopiperazines [PDF]
Angewandte Chemie, 2011 Sulfurs in action A practical and simple method for the introduction of sulfur atoms into 2,5-diketopiperazines (I) under mild conditions has been developed leading to more or less complex epidithiodiketopiperazines (II) and bis-methylthiodiketopiperazines (III).
K C, Nicolaou +3 more
openaire +2 more sources
Aldol condensations on a 3-alkylidene-2,5-diketopiperazine - synthesis of two marine natural products [PDF]
, 2018 The synthesis of two marine natural products containing a 3-alkylidene-6-arylidene-2,5-diketopiperazine scaffold by employing two consecutive aldol condensations starting with 1,4-diacetyl-2,5-diketopiperazine is reported.
Fairhurst, Magnus John E. +7 more
core +1 more source
Molecules, 2015 The coupling of haloarenes to styrenes and 1,1-diarylethenes has been achieved with potassium tert-butoxide in the presence of N,N'-dialkyldiketopiperazines.
Eswararao Doni +2 more
doaj +1 more source
Frontiers in Microbiology, 2022 The quorum-sensing (QS) cascade is responsible for the colonization and phenotypic behavior of the pathogenic organism and the regulation of diverse signal molecules.
Chintan Kapadia +8 more
doaj +1 more source
Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators
Molecules, 2017 It has been proven that specific isoforms of human carbonic anhydrase (hCA) are able to fine-tune physiological pathways connected to signal processing, and that decreased CAs expression negatively influences cognition, leading to mental retardation ...
Adriano Mollica +6 more
doaj +1 more source
, 2019 Eight new diketopiperazine-type alkaloids including four oxepin-containing diketopiperazine-type alkaloids, oxepinamides H–K (1–4), and four 4-quinazolinone alkaloids, puniceloids A–D (5–8), together with two known analogues (9 and 10), were isolated ...
Zhihui Zheng +11 more
core +1 more source
Five- and Six-Membered Ring Opening of Pyroglutamic Diketopiperazine
, 2016 A variety of ring-opening reactions of pyroglutamic diketopiperazine at both the five-membered and six-membered rings is described. Mild, basic conditions facilitate nucleophilic attack by amines at the diketopiperazine carbonyls giving pyroglutamides in
Dennis A. Parrish (3031077) +1 more
core +1 more source
Antimicrobial and Biofilm Inhibiting Diketopiperazines
Current Medicinal Chemistry, 2012 Diketopiperazines are the smallest cyclic peptides known. 90% of Gram-negative bacteria produce diketopiperazines and they have also been isolated from Gram-positive bacteria, fungi and higher organisms. Biosynthesis of cyclodipeptides can be achieved by dedicated nonribosomal peptide synthetases or by a novel type of synthetases named cyclopeptide ...
de Carvalho, M P, Abraham, Wolf-Rainer
openaire +3 more sources
Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups
Angewandte Chemie International Edition, EarlyView.A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari +10 more
wiley +1 more source
Evidence of diketopiperazine and oxazolone structures for HA b2+ ion.
, 2009 International audiencePeptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure. IRMPD spectroscopy combined with computational modeling and gas-phase H/D exchange was used to study the structure of the b(2)(+) ion from ...
Somogyi, Arpád +5 more
core +1 more source