Results 11 to 20 of about 3,309 (181)
Conformationally Defined Alkaloidal Building Units for the Controlled Formation of Nanoscale Supramolecular Morphologies. [PDF]
Chem Asian JStructural and stereochemical modulation of diketopiperazine (DKP)–fused bispyrrolidinoindoline (BPI) building units enables precise control of conformation and intermolecular interactions, achieving well‐ordered nanoscale morphologies. Substituents and configuration variations control the morphology of BPI–DKP assemblies, producing block‐like or ...
Oki F +9 more
europepmc +2 more sources
A Bifunctional Cytochrome P450 Enzyme Catalyzes Hydroxylation and Aryl-Aryl Ether Formation in the Biosynthesis of Emestrin. [PDF]
ChemistryConversion of emestrin J (5) to emestrin (1) by three P450 enzymes from the cluster (eme) in Emericella quadrilineata. EmeO acts as a bifunctional enzyme for the construction of the 15‐membered lactone ring via an aryl‐aryl ether bond formation and simultaneous hydroxylation between phenolic and nonphenolic aromatic rings, while EmeE and EmeR install ...
Chen YC, Wu JJ, Chen MH, Li SM.
europepmc +2 more sources
Characterisation of Cooked Cheese Flavour: Non-Volatile Components
Foods, 2023 This work examined the role of selected non-volatile compounds in cooked cheese flavour, both as tastants and as precursors of aroma generation in the Maillard reaction.
Rosa C. Sullivan +5 more
doaj +1 more source
Molecules, 2021 Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target for drug development based on its efficacy for treatment of erectile dysfunction.
Adam Mieczkowski +12 more
doaj +1 more source
α-Glucosidase Inhibitors from Two Mangrove-Derived Actinomycetes
Molecules, 2023 α-Glucosidase (AGS) inhibitors have been regarded as an ideal target for the management of type 2 diabetes mellitus (T2DM) since they can maintain an acceptable blood glucose level by delaying the digestion of carbohydrates and diminishing the absorption
Xuejun Lu +11 more
doaj +1 more source
Applied Sciences, 2021 Chemical investigations of Aquimarina sp. MC085, which suppressed TGF-β-induced epithelial–mesenchymal transition (EMT) in A549 human lung cancer cells, led to the isolation of compounds 1–3.
Myong Jin Lee +7 more
doaj +1 more source
Marine Drugs, 2011 While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2),
Dianne M. Tapiolas +6 more
doaj +1 more source
Marine Drugs, 2021 The Persian Gulf is a unique and biologically diverse marine environment dominated by invertebrates. In continuation of our research interest in the chemistry and biological activity of marine sponges from the Persian Gulf, we selected the excavating ...
Reza Mohsenian Kouchaksaraee +4 more
doaj +1 more source
Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18
Pharmaceutical Biology, 2021 Context Streptomyces species are prolific sources of bioactive secondary metabolites known especially for their antimicrobial and anticancer activities.
Babita Paudel +8 more
doaj +1 more source
Molecules, 2023 Ochratoxin A is historically the most notable secondary metabolite of Aspergillus ochraceus on account of its toxicity to animals and fish. Currently, over 150 compounds of diverse structure and biosynthesis is a challenge to predict the array for any ...
Peter Mantle +2 more
doaj +1 more source