Results 41 to 50 of about 5,442 (212)

Synthesis of Proline-Based Diketopiperazine Scaffolds

, 2016
A number of natural products with interesting biological properties are based on a diketopiperazine scaffold. In this context, we have developed a diversity oriented and efficient synthetic strategy to highly functionalized proline-based ...
A. Beitat (2370445), W. Maison (2370442), N. Deppermann (2370439), A. H. G. P. Prenzel (2370436)   +3 more
core   +3 more sources

Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, Marchantia polymorpha L.

Molecules, 2021
Liverwort endophytes could be a source of new biologically active substances, especially when these spore-forming plants are known to produce compounds that are not found in other living organisms.
Mateusz Stelmasiewicz, Łukasz Świątek, Agnieszka Ludwiczuk   +2 more
doaj   +1 more source

Dietary Artificial Sweeteners: From Chemical Transformation in Food to Gut Microbial Processing

ChemFoodChem, EarlyView.
This review article unites classical and recent findings on the stability of artificial sweeteners in food. The focus is on ten sweeteners approved in the European Union: their chemical stability during processing and storage, individual degradation products, and their interactions with the intestinal microbiota.
Jürgen Lassak, Michael Hellwig
wiley   +1 more source

Total Synthesis of Anti-microtubule Diketopiperazine Derivatives:  Phenylahistin and Aurantiamine

, 2016
Total Synthesis of Anti-microtubule Diketopiperazine Derivatives:  Phenylahistin and ...
Sumie Orikasa (2114740), Koji Tanaka (559903), Yoshiaki Kiso (2114749), Yoshio Hayashi (111974), Kaneo Kanoh (2114767)   +4 more
core   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

Marine Drugs, 2019
Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4 ...
Jiansen Hu, Zheng Li, Jieyu Gao, Hongtao He, Huanqin Dai, Xuekui Xia, Cuihua Liu, Lixin Zhang, Fuhang Song   +8 more
doaj   +1 more source

The Degradation Product of Ramipril Is Potentially Carcinogenic, Genotoxic and Mutagenic

Applied Sciences, 2023
(1) Background: The aim of this study was to identify the degradation product of ramipril (RAM) formed under dry air and to verify its potential modes of carcinogenicity. We intended to check whether its formation and presence in final dosage forms could
Katarzyna Regulska, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Beata J. Stanisz   +3 more
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Two Additional New Compounds from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3

Molecules, 2016
Two additional new compounds, pseudellone D (1) and (5S,6S)-dihydroxylasiodiplodin (3), along with the two known compounds lasiodipline F (2), (5S)-hydroxylasiodiplodin (4) were isolated from the marine-derived fungus Pseudallescheria ellipsoidea F42-3 ...
Kun-Teng Wang, Meng-Yang Xu, Wei Liu, Hou-Jin Li, Jun Xu, De-Po Yang, Wen-Jian Lan, Lai-You Wang   +7 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance Trichoderma gamsii ICC080

EFSA Journal, Volume 24, Issue 11, November 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Sweden, and co‐rapporteur Member State, Italy, for the pesticide active substance Trichoderma gamsii ICC080 are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Teresa Chavez Capilla, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Julia Fabrega, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Adriana Scattareggia Marchese, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source