Results 51 to 60 of about 5,442 (212)

A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens

Marine Drugs, 2019
Thirteen nitrogen-containing molecules (1a/1b and 2−12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids.
Germana Esposito, Linh H. Mai, Arlette Longeon, Alfonso Mangoni, Emilie Durieu, Laurent Meijer, Rob Van Soest, Valeria Costantino, Marie-Lise Bourguet-Kondracki   +8 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance Trichoderma asperellum ICC012

EFSA Journal, Volume 24, Issue 11, November 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Sweden, and co‐rapporteur Member State, France, for the pesticide active substance Trichoderma asperellum ICC012 are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Teresa Chavez Capilla, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Julia Fabrega, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza, Adriana Scattareggia Marchese   +48 more
wiley   +1 more source

Unified Approach for the Synthesis of Close Analogues of Reverse‐Prenylated Hexahydropyrrolo Indole Alkaloids

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
A simple, modular, and unified strategy for the synthesis of reverse‐prenylated hexahydropyrrolo indole alkaloids has been developed. An unusual retrosynthetic disconnection allows for the late introduction of a side chain, which distinguishes many members of this class of natural products.
Daniel Schmelzer, Carina S. Wencke, Christian B. W. Stark   +2 more
wiley   +1 more source

Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp.

, 2016
A new dimeric diketopiperazine, naseseazine C, and the known naseseazines A and B were isolated from solid culture extracts of an Australian marine sediment derived Streptomyces species.
Kurtboke, D I, Grkovic, Tanja, Carroll, Anthony R, Buedenbender, Larissa, Avery, Vicky M, Kurtboke, D Ipek, Duffy, Sandra   +6 more
core   +1 more source

Isolation and Identification of Cis-2,5-Diketopiperazine from a Novel Bacillus Strain and Synthesis of Its Four Stereoisomers

Marine Drugs
The Bacillus horneckiae-like strain 2011SOCCUF3 was isolated from the marine sponge Spongia officinalis and its metabolome was studied for secondary metabolites with antimicrobial activity.
Alan M. C. Obled, Refaat B. Hamed, Edward Spence, Marija K. Zacharova, Sunil V. Sharma, Yunpeng Wang, Rosemary Lynch, Helen Connaris, Adina Tatheer, Marie-Lise Bourguet-Kondracki, Gordon J. Florence, Rebecca J. M. Goss   +11 more
doaj   +1 more source

A Diketopiperazine, Cyclo-(L-Pro-L-Ile), Derived From Bacillus thuringiensis JCK-1233 Controls Pine Wilt Disease by Elicitation of Moderate Hypersensitive Reaction

Frontiers in Plant Science, 2020
Pine wilt disease (PWD) caused by the pine wood nematode (PWN) Bursaphelenchus xylophilus is one of the devastating diseases affecting pine forests worldwide.
Ae Ran Park, Se-In Jeong, Hee Won Jeon, Jueun Kim, Namgyu Kim, Manh Tuan Ha, Mohamed Mannaa, Junheon Kim, Chul Won Lee, Byung Sun Min, Young-Su Seo, Jin-Cheol Kim   +11 more
doaj   +1 more source

Isolation and identification of a new tetrahydro-β-carboline diketopiperazine from a predominant endophytic fungus in ancient Camellia taliensis

Guangxi Zhiwu, 2023
To investigate the chemical constituents of Diaporthe tectonigena, a predominant endophytic fungus in the ancient tea tree of Camellia taliensis, the rice solid-state fermentation extract was isolated and purified by silica gel, Diaion HP20 and Sephadex ...
Luyao CHENG, Xiaoxue CHEN, Yingjun ZHANG, Yonglin HUANG, Guolei ZHU, Na LI, Ping ZHAO   +6 more
doaj   +1 more source

The Fluorescence of Tyrosyl and Tryptophanyl Diketopiperazines

Journal of Biological Chemistry, 1968
Abstract The influence of the peptide group on the quantum yield of phenol and indole has been evaluated from fluorescence measurements on the diketopiperazines of the two chromophores. Strong quenching of both groups occurs in water which is almost completely eliminated in dioxane and dimethyl sulfoxide.
H, Edelhoch, R S, Bernstein, M, Wilchek
openaire   +2 more sources

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

The Novel Diketopiperazine Derivative, Compound 5-3, Selectively Inhibited the Proliferation of FLT3-ITD Mutant Acute Myeloid Leukemia (AML) Cells

Marine Drugs
The internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) is associated with high recurrence and mortality rates in acute myeloid leukemia (AML), making it a critical target for anti-AML therapies.
Shijie Bi, Yating Cao, Shiyuan Fang, Yanyan Chu, Zixuan Zhang, Meng Li, Rilei Yu, Jinbo Yang, Yu Tang, Peiju Qiu   +9 more
doaj   +1 more source