Results 61 to 70 of about 3,309 (181)

An Isotopic Ratio Outlier Analysis Approach for Global Metabolomics of Biosynthetically Talented Actinomycetes

Metabolites, 2019
Actinomycetes are powerhouses of natural product biosynthesis. Full realization of this biosynthetic potential requires approaches for recognizing novel metabolites and determining mediators of metabolite production.
Jordan Carey, Thanh Nguyen, Jennifer Korchak, Christopher Beecher, Felice de Jong, Amy L. Lane   +5 more
doaj   +1 more source

A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

Frontiers in Microbiology, 2018
Cyclodipeptide synthases (CDPSs) use as substrates two amino acids activated as aminoacyl-tRNAs to synthesize cyclodipeptides in secondary metabolites biosynthetic pathways.
Muriel Gondry, Isabelle B. Jacques, Robert Thai, Morgan Babin, Nicolas Canu, Jérôme Seguin, Pascal Belin, Jean-Luc Pernodet, Mireille Moutiez   +8 more
doaj   +1 more source

Crystal structures of the dimethyl sulfoxide solvate of 3,6-bis(indol-3-yl)-1,4-dimethylpiperazine-2,5-dione and of the dimethyl sulfoxide and tetrahydrofuran solvates of 1,4-dimethyl-3,6-bis(2-methylindol-3-yl)piperazine-2,5-dione

Acta Crystallographica Section E: Crystallographic Communications
The syntheses and structures of the dimethyl sulfoxide (DMSO) solvate of 3,6-bis(indol-3-yl)-1,4-dimethylpiperazine-2,5-dione, C11H10N2O (I), and of the dimethyl sulfoxide and tetrahydrofuran (THF) solvates of 1,4-dimethyl-3,6-bis(2-methylindol-3-yl ...
Clifford W. Padgett, Will E. Lynch, Stephen N. Crooke, Christine R. Whitlock   +3 more
doaj   +1 more source

Inhibition of Aflatoxin Production in Aspergillus flavus by a Klebsiella sp. and Its Metabolite Cyclo(l-Ala-Gly)

Toxins
During an experiment where we were cultivating aflatoxigenic Aspergillus flavus on peanuts, we accidentally discovered that a bacterium adhering to the peanut strongly inhibited aflatoxin (AF) production by A. flavus.
Shohei Sakuda, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa   +8 more
doaj   +1 more source

Biosynthesis of a Novel Diketopiperazine Aspkyncin Incorporating a Kynurenine Unit from Aspergillus aculeatus

Journal of Fungi
The simplest cyclo-peptides, also known as diketopiperazines (DKPs), are widespread in nature. The growing interest in these simplest cyclo-peptides is driven by their significant potential for therapeutic applications.
Dekun Kong, Xin Wang, Li Liu
doaj   +1 more source

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

Beilstein Journal of Organic Chemistry, 2013
Aiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP (diketopiperazine)-based peptidomimetic scaffold capable of arranging in an unusual α-turn conformation.
Francesco Airaghi, Andrea Fiorati, Giordano Lesma, Manuele Musolino, Alessandro Sacchetti, Alessandra Silvani   +5 more
doaj   +1 more source

The Mode of Action of Cyclo(l-Ala-l-Pro) in Inhibiting Aflatoxin Production of Aspergillus flavus

Toxins, 2017
Cyclo(l-Ala-l-Pro) inhibits aflatoxin production in aflatoxigenic fungi without affecting fungal growth. The mode of action of cyclo(l-Ala-l-Pro) in inhibiting aflatoxin production of Aspergillus flavus was investigated. A glutathione S-transferase (GST)
Kurin Iimura, Tomohiro Furukawa, Toshiyoshi Yamamoto, Lumi Negishi, Michio Suzuki, Shohei Sakuda   +5 more
doaj   +1 more source

Streptomyces nigra sp. nov. Is a Novel Actinobacterium Isolated From Mangrove Soil and Exerts a Potent Antitumor Activity in Vitro

Frontiers in Microbiology, 2018
A new bacterial strain, designated 452T, was isolated from the rhizosphere soil of the mangrove Avicennia marina in China. As determined, its cell wall peptidoglycan contained LL-diaminopimelic acid; MK-9(H8) and MK-9(H6) were the major isoprenoid ...
Can Chen, Yanghui Ye, Ruijun Wang, Yinglao Zhang, Chen Wu, Sanjit C. Debnath, Zhongjun Ma, Jidong Wang, Min Wu   +8 more
doaj   +1 more source

Solid-Phase Synthesis of Methyl N-(pyrimidin-2-yl)glycinate

Molecules, 2003
A versatile method for the preparation of N-heteroaryl substituted aminoacid derivatives is suggested. The method avoids facile diketopiperazine formation.
Eugene V. Babaev, Denis S. Ermolat'ev
doaj   +1 more source

Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs

Pharmaceuticals, 2010
We developed an efficient, stereoselective synthetic method for the diketopiperazine moiety of neoechinulin A and its derivatives. The intramolecular cyclization at 80 ºC proceeded with minimal racemization of the stereogenic center at C-12 on ...
Toshiaki Aoki, Kensuke Ohnishi, Masaaki Kimoto, Satoshi Fujieda, Kouji Kuramochi, Toshifumi Takeuchi, Atsuo Nakazaki, Nobuo Watanabe, Fumio Sugawara, Takao Arai, Susumu Kobayashi   +10 more
doaj   +1 more source