Results 81 to 90 of about 5,442 (212)

A Delineation Of Diketopiperazine Self-Assembly Processes: Understanding The Molecular Events Involved In N\u3csup\u3eΕ\u3c/sup\u3e-(Fumaroyl)Diketopiperazine Of L-Lys (Fdkp) Interactions

, 2008
The N-epsilon-fumaroylated diketopiperazine of L-Lys (FDKP, 1) self-assembles into microparticles that can be used for pulmonary drug delivery. When these particles are formulated with insulin, the resultant powder (Technosphere Insulin) provides a novel
Kaur, Navneet, Kraft, Kelly S., Breitbeil, Fred, Zhou, Bo, Hardy, Katherine   +4 more
core   +2 more sources

A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

Frontiers in Microbiology, 2018
Cyclodipeptide synthases (CDPSs) use as substrates two amino acids activated as aminoacyl-tRNAs to synthesize cyclodipeptides in secondary metabolites biosynthetic pathways.
Muriel Gondry, Isabelle B. Jacques, Robert Thai, Morgan Babin, Nicolas Canu, Jérôme Seguin, Pascal Belin, Jean-Luc Pernodet, Mireille Moutiez   +8 more
doaj   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122

, 2022
Chevalinulins A (1) and B (2), two indole diketopiperazine alkaloids containing an unprecedented spiro­[bicyclo[2.2.2]­octane-diketopiperazine] skeleton, together with a known analogue neoechinulin B (3), were isolated from the deep-sea cold-seep-derived
Bin-Gui Wang (536712), Xin Li (51274), Sui-Qun Yang, Xin Li, Xiao-Ming Li, Ke-Chun Liu (809887), Pei-Hai Li, Sui-Qun Yang (4724313), Pei-Hai Li (12368456), Li-Hong Yan, Ke-Chun Liu, Li-Hong Yan (12368453), Bin-Gui Wang, Xiao-Ming Li (1523278)   +13 more
core   +1 more source

Crystal structures of the dimethyl sulfoxide solvate of 3,6-bis(indol-3-yl)-1,4-dimethylpiperazine-2,5-dione and of the dimethyl sulfoxide and tetrahydrofuran solvates of 1,4-dimethyl-3,6-bis(2-methylindol-3-yl)piperazine-2,5-dione

Acta Crystallographica Section E: Crystallographic Communications
The syntheses and structures of the dimethyl sulfoxide (DMSO) solvate of 3,6-bis(indol-3-yl)-1,4-dimethylpiperazine-2,5-dione, C11H10N2O (I), and of the dimethyl sulfoxide and tetrahydrofuran (THF) solvates of 1,4-dimethyl-3,6-bis(2-methylindol-3-yl ...
Clifford W. Padgett, Will E. Lynch, Stephen N. Crooke, Christine R. Whitlock   +3 more
doaj   +1 more source

Diastereoselective Synthesis of Diketopiperazine Bis-α,β-epoxides

, 2016
Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-α,β-epoxides via the oxidation of exocyclic ...
Shin Ando (1310043), Amy L. Grote (2230132), Kazunori Koide (779946)   +2 more
core   +3 more sources

Inhibition of Aflatoxin Production in Aspergillus flavus by a Klebsiella sp. and Its Metabolite Cyclo(l-Ala-Gly)

Toxins
During an experiment where we were cultivating aflatoxigenic Aspergillus flavus on peanuts, we accidentally discovered that a bacterium adhering to the peanut strongly inhibited aflatoxin (AF) production by A. flavus.
Shohei Sakuda, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa   +8 more
doaj   +1 more source

Biosynthesis of a Novel Diketopiperazine Aspkyncin Incorporating a Kynurenine Unit from Aspergillus aculeatus

Journal of Fungi
The simplest cyclo-peptides, also known as diketopiperazines (DKPs), are widespread in nature. The growing interest in these simplest cyclo-peptides is driven by their significant potential for therapeutic applications.
Dekun Kong, Xin Wang, Li Liu
doaj   +1 more source

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

Beilstein Journal of Organic Chemistry, 2013
Aiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP (diketopiperazine)-based peptidomimetic scaffold capable of arranging in an unusual α-turn conformation.
Francesco Airaghi, Andrea Fiorati, Giordano Lesma, Manuele Musolino, Alessandro Sacchetti, Alessandra Silvani   +5 more
doaj   +1 more source

The Mode of Action of Cyclo(l-Ala-l-Pro) in Inhibiting Aflatoxin Production of Aspergillus flavus

Toxins, 2017
Cyclo(l-Ala-l-Pro) inhibits aflatoxin production in aflatoxigenic fungi without affecting fungal growth. The mode of action of cyclo(l-Ala-l-Pro) in inhibiting aflatoxin production of Aspergillus flavus was investigated. A glutathione S-transferase (GST)
Kurin Iimura, Tomohiro Furukawa, Toshiyoshi Yamamoto, Lumi Negishi, Michio Suzuki, Shohei Sakuda   +5 more
doaj   +1 more source