Results 201 to 210 of about 10,177 (227)
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EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES
International Journal of Peptide and Protein Research, 1980Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Asp‐L‐His) and cyclo‐(L‐Glu‐L‐His). The side chain conformations have been studied for various DKP ring structures, demonstrating that distortions can modify the stability of some conformations by favouring peptide backboneside chain or side chain ‐ side chain ...
M. GENEST, M. PTAK
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Cyclic dipeptides exhibit potency for scavenging radicals
Bioorganic & Medicinal Chemistry, 2012Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)
Tadashi, Furukawa +6 more
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Linear and cyclic dipeptides with antimalarial activity
Bioorganic & Medicinal Chemistry Letters, 2012Several natural and synthetic polypeptides possess important antimalarial activity. Shorter peptides with potent antimalarial activity have also been described, among them linear di-, tri-, tetra- and pentapeptides and their cyclic analogs. In an attempt to find dipeptides with antimalarial activities we show that linear and cyclic dipeptides, the ...
Lemuel, Pérez-Picaso +4 more
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Peptides, 1995
Cyclic dipeptides are among the simplest peptide derivatives commonly found in nature. Most cyclic dipeptides found to date appear to have emerged as by-products of fermentation and food processing. However, many are endogenous to members of animal and plant kingdoms; these include cyclo(Pro-Leu), cyclo(Pro-Val), cyclo(Pro-Phe), cyclo(Ala-Leu), cyclo ...
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Cyclic dipeptides are among the simplest peptide derivatives commonly found in nature. Most cyclic dipeptides found to date appear to have emerged as by-products of fermentation and food processing. However, many are endogenous to members of animal and plant kingdoms; these include cyclo(Pro-Leu), cyclo(Pro-Val), cyclo(Pro-Phe), cyclo(Ala-Leu), cyclo ...
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Synthesis of New Functionalized Cyclic Dipeptide
Synthetic Communications, 1997Abstract An efficient method has been developed for the synthesis of the functionalized cyclic dipeptide 6. The key step involves cyclisation of the linear dipeptide prepared by coupling a suitably protected β-amino acid with N-benzyl-t-butylglycinate.
O. El Mahdi +4 more
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Antimicrobial activity of selected cyclic dipeptides.
Die Pharmazie, 1999Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the
M, Graz +4 more
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Synthesis of cyclic ketomethylene dipeptide derivatives
Tetrahedron, 1992Abstract —Methyl 6-aralkyl-2,5-diketopiperidine-3-carboxylates derived from L-Phe and L-Trp, and their 3-substituted analogues in which the 3-substituent is the side chain of Phe, Asp and Ala have been synthesized. Cycle[Trpψ(COCH2)Gly] and cycle[Pheψ(COCH2)-ξ-Phe] have been also prepared.
M.J. Domínguez +2 more
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Quantum chemical study of cyclic dipeptides
International Journal of Quantum Chemistry, 2006AbstractThe preferred conformations of cyclic dipeptides were first studied systemically using the density functional theory (DFT) B3LYP method at the 6‐31G(d) level. The structural characteristics of cyclic dipeptides were revealed, most of which have not been confirmed until now.
Yanyan Zhu +3 more
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Hydrophobic cyclic dipeptides as M+/Cl−carriers
Chemical Communications, 2023An interplay of ester and amide units for transmembrane KCl co-transport using simple cyclic dipeptides.
Umatai A. Hale, Nandita Madhavan
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The optical properties of tyrosine‐containing cyclic dipeptides
Biopolymers, 1977AbstractThe chiroptical properties of the cyclic dipeptides cyclo (L‐alanyl‐L‐tyrosine) and cyclo(L‐tyrosyl‐L‐tyrosine) have been investigated as a function of molecular conformation. Theoretical optical calculations and conformational energy calculations have been carried out as a function of the side‐chain dihedral angles χ1 and χ2, and as a function
J W, Snow, T M, Hooker, J A, Schellman
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