Results 201 to 210 of about 4,865 (234)

Synthesis of New Functionalized Cyclic Dipeptide

Synthetic Communications, 1997
Abstract An efficient method has been developed for the synthesis of the functionalized cyclic dipeptide 6. The key step involves cyclisation of the linear dipeptide prepared by coupling a suitably protected β-amino acid with N-benzyl-t-butylglycinate.
O. El Mahdi, J. P. Lavergne, J. Martinez, Ph. Viallefont, C. Riche   +4 more
openaire   +1 more source

Two-Dimensional Coordination Networks from Cyclic Dipeptides

Journal of the American Chemical Society, 2020
Peptide-based biomimetic nanostructures and metal-organic coordination networks on surfaces are two promising classes of hybrid materials which have been explored recently. However, despite the great versatility and structural variability of natural and synthetic peptides, the two directions have so far not been merged in fabrication of metal-organic ...
Yuanyuan Guo, Ajiguli Nuermaimaiti, Niels Due Kjeldsen, Kurt V. Gothelf, Trolle R. Linderoth   +4 more
openaire   +2 more sources

EMPIRICAL CALCULATIONS ON CYCLIC DIPEPTIDES

International Journal of Peptide and Protein Research, 1978
Empirical conformational energy calculations were carried out for the dipeptides cyclo‐(L‐Ser‐L‐His) and cyclo‐(L‐Thr‐L‐His). Various DKP structures have been investigated to study side chain conformations through the DKP ring deformations, and prevalent conformers of monosubstituted and disubstituted dipeptides are discussed.
M, Genest, M, Ptak
openaire   +2 more sources

Quantum chemical study of cyclic dipeptides

International Journal of Quantum Chemistry, 2006
AbstractThe preferred conformations of cyclic dipeptides were first studied systemically using the density functional theory (DFT) B3LYP method at the 6‐31G(d) level. The structural characteristics of cyclic dipeptides were revealed, most of which have not been confirmed until now.
Yanyan Zhu, Mingsheng Tang, Xiaoyu Shi, Yufen Zhao   +3 more
openaire   +1 more source

Synthesis of cyclic ketomethylene dipeptide derivatives

Tetrahedron, 1992
—Methyl 6-aralkyl-2,5-diketopiperidine-3-carboxylates derived from L-Phe and L-Trp, and their 3-substituted analogues in which the 3-substituent is the side chain of Phe, Asp and Ala have been synthesized. Cycle[Trpψ(COCH2)Gly] and cycle[Pheψ(COCH2)-ξ-Phe] have been also prepared.3-Substituted methyl 6-arakyl-2,5-diketopiperidine-3-carboxylates 11ab ...
Domínguez, María José, González-Muñiz, Rosario, García-López, M. Teresa   +2 more
openaire   +2 more sources

Antimicrobial activity of selected cyclic dipeptides.

Die Pharmazie, 1999
Cyclic dipeptides are products of rational drug design, which may exhibit both antimicrobial and antitumor properties. The aim of this study was to investigate both the antimicrobial effects of the cyclic dipeptides cyclo(L-phenylalanyl-L-prolyl), cyclo(L-tyrosyl-L-prolyl), cyclo(L-tryptophanyl-L-prolyl) and cyclo(L-tryptophanyl-L-tryptophanyl) and the
M, Graz, A, Hunt, H, Jamie, G, Grant, P, Milne   +4 more
openaire   +2 more sources

Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba

Archives of Microbiology, 2014
Nocardiopsis alba is frequently isolated from environment and has recently been suggested as a casual symbiotic actinobacterium of diverse invertebrates. Using activity-guided fractionation, we purified two antibacterial cyclic dipeptides, cyclo(ΔPhe-ΔLeu) (albonoursin) and cyclo(ΔmTyr-ΔLeu), from a culture of Nocardiopsis alba ATCC BAA-2165.
Yongli, Li, Ying-Mi, Lai, Yi, Lu, Yu-Liang, Yang, Shawn, Chen   +4 more
openaire   +2 more sources

Theoretical UV Circular Dichroism of Aliphatic Cyclic Dipeptides

The Journal of Physical Chemistry A, 2005
Four cyclic dipeptides (piperazine-2,5-diones), cyclo(L-Pro-Gly), cyclo(L-Pro-L-Leu), cyclo(L-Ala-L-Ala), and cyclo(L-Pro-L-Ala), were modeled from crystal structure data. Conformations resulting from energy minimization using molecular mechanics were compared with traditional ab initio and density functional theory geometric optimizations for each ...
Kristine L, Carlson, Stephen L, Lowe, Mark R, Hoffmann, Kathryn A, Thomasson   +3 more
openaire   +2 more sources

Molecular Self‐Assembly of Cyclic Dipeptide Derivatives and Their Applications

ChemPlusChem, 2016
AbstractCyclic dipeptides (CDPs) are heterocyclic 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take part in intermolecular interactions. Strong intermolecular interactions driven by unique hydrogen bonding patterns render CDPs with a high propensity to ...
Shivaprasad Manchineella, T. Govindaraju
openaire   +2 more sources

Asymmetric catalysis of the Strecker amino acid synthesis by a cyclic dipeptide

Amino Acids, 1996
A novel cyclic dipeptide -cyclo[(S)-His-(S)-NorArg] - has been prepared which catalyzes an enantioselective version of the Strecker amino acid synthesis. The catalyst, when present in 2 mol % quantity in methanol solution, catalyzes the addition of hydrogen cyanide toN-alkylimines to affordα-amino nitriles in high yield and high enantiomeric excess ...
M S, Iyer, K M, Gigstad, N D, Namdev, M, Lipton   +3 more
openaire   +2 more sources