Results 111 to 120 of about 72,449 (334)

Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli [PDF]

, 2018
Cyclic di-GMP (c-di-GMP) is an almost universal bacterial second messenger involved in the regulation of cell surface-associated traits and the persistence of infections.
Massa, Claudia, Schirmer, Tilman, Zähringer, Franziska   +2 more
core  

Actions of chorionic gonadotropin upon cyclic amp and cyclic gmp in isolated testicular interstitial cells [PDF]

, 1976
Carolyn Williams, Kevin Catt
openalex   +1 more source

Cyclic GMP and cyclic GMP phosphodiesterase in the cell cycle of Tetrahymena pyriformis [PDF]

FEBS Letters, 1976
M.G. Graves, B.E.P. Swoboda, J.R. Dickinson   +2 more
openaire   +3 more sources

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

Understanding the errors of SHAPE-directed RNA structure modeling

, 2011
Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms.
Aviran S., Brunel C., Butler E. B., Byrne R. T., Cate J. H., Christopher C. VanLang, Collins K., Correll C. C., Cruz J. A., Darty K., Das R., Das R., Deigan K. E., Efron B., Efron B., Felsenstein J., Gesteland R. F., Hickey D. R., Hofacker I. L., Kladwang W., Kladwang W., Kulshina N., Kwon M., Lemay J. F., Leontis N. B., Levitt M., Mandal M., Mandal M., Mathews D. H., Mathews D. H., Mills D. R., Mitra S., Mortimer S. A., Noller H. F., Pablo Cordero, Panning B., Pedersen J. S., Regulski E. E., Rhiju Das, Russell R., Russell R., Serganov A., Smith K. D., Staley J. P., Sudarsan N., Sussman J. L., Takamoto K., Vasa S. M., Watts J. M., Wilkinson K. A., Wilkinson K. A., Winkler W. C., Wipapat Kladwang, Yoon S.   +53 more
core   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Modification of human DNA-dependent RNA polymerase activity by cyclic GMP [PDF]

, 1977
Leslie D. Johnson, John W. Hadden
openalex   +1 more source

Genetic Impacts on the Structure and Mechanics of Cellulose Made by Bacteria

Advanced Science, EarlyView.
A genetic mutation in a protease of a cellulose‐overproducing evolved bacterium significantly affects the proteome, structure, and mechanical properties of bio‐fabricated cellulose pellicles. By overexpressing synthase proteins that build the cellulose‐forming biological machinery of the cell, the evolved bacterium generates dense, stiff, and strong ...
Julie M. Laurent, Mathias Steinacher, Anton Kan, Maximilian Ritter, Mario Leutert, Siiri Bienz, David Häberlin, Naresh Kumar, André R. Studart   +8 more
wiley   +1 more source

Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target.

PLoS ONE, 2014
With the inevitable selection of resistance to antimalarial drugs in treated populations, there is a need for new medicines to enter the clinic and new targets to progress through the drug discovery pipeline.
Rita Tewari, Eva-Maria Patzewitz, Benoit Poulin, Lindsay Stewart, David A Baker   +4 more
doaj   +1 more source

Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

Advanced Science, EarlyView.
Shear‐activated nanoparticles carrying nitroglycerin selectively target high‐shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at‐risk brain without systemic side effects. This novel approach significantly improves outcomes in animal models, outperforming conventional nitroglycerin delivery.
Magdalena Litman, Sara Azarpeykan, Rebecca J Hood, Kristy Martin, Debbie Pepperall, Daniel Omileke, Fern Williams, Oktay Uzun, Deen Bhatta, Yuen K Yong, Alex Chan, Nicholas Hough, Sarah Johnson, Pablo Garcia Bermejo, Ferdinand Miteff, Carlos Garcia Esperon, Yvonne Couch, Alastair M Buchan, Neil J Spratt, Netanel Korin, Donald E Ingber, Daniel J Beard   +21 more
wiley   +1 more source