Results 121 to 130 of about 450,778 (258)

Yc-1 Potentiates Nitric Oxide-Induced Relaxation in Guinea-Pig Trachea

, 2009
1 The effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1- benzylindazole) on tension, levels of cyclic GMP and cyclic AMP were investigated in guinea-pig trachea.
鄧哲明, Hwang, Tsong-Long; Wu, Chin-Chung; Teng, Che-Ming   +1 more
core  

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Oxygen Partial Pressure as a Kinetic Descriptor for Single‐Crystal Morphology in Mid‐Nickel Layered Cathodes

Advanced Science, EarlyView.
Scalable synthesis of single‐crystal mid‐nickel cathodes demands precise kinetic control over competing densification and grain growth. Oxygen partial pressure emerges as a quantitative descriptor of effective grain‐boundary mobility, acting through changes in the apparent sintering activation barrier.
Hyeonho Park, Sushil Kumar, Sangbeom Kim, Ho Choi, Youngmin Jeon, Taeju Bak, Jisook Hong, M. P. Gururajan, Youngjin Kim, Kyoungdoc Kim   +9 more
wiley   +1 more source

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messengers Cyclic di-GMP and Cyclic AMP-GMP

, 2016
Cyclic dinucleotides are an important class of signaling molecules that regulate a wide variety of pathogenic responses in bacteria, but tools for monitoring their regulation in vivo are lacking.
Colleen A. Kellenberger (1340292), Jade Sales-Lee (761232), Stephen C. Wilson (1974652), Ming C. Hammond (761236)   +3 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are intracellular mediators of innate immune responses to cytosolic pathogen-derived and host DNA.
Akshay Rohilla, Alok Kumar Singh, Benjamin Koleske, Geetha Srikrishna, William R. Bishai   +4 more
doaj   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect

, 1977
Modifications in the cyclic nucleotide systems favoring the expression of cyclic GMP effects were found to occur in the transplanted fast-growing Morris hepatoma 3924A.
Shoji, Mamoru, Kuo, J.F, Morris, Harold P, Davis, Craig W, Brackett, Nancy L   +4 more
core   +1 more source

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin

EMBO Reports
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE.
Siqi Yu, Zheyao Hu, Xiaoting Xu, Xiaoran Liang, Jiayi Shen, Min Liu, Mingxi Lin, Hong Chen, Jordi Marti, Sheng-ce Tao, Zhaowei Xu   +10 more
doaj   +1 more source