Results 121 to 130 of about 43,561 (311)

Synergistic growth stimulation of Conn’s adenoma cells by cyclic AMP and GMP

, 1979
Synergistic growth stimulation of Conn’s adenoma cells by cyclic AMP and GMP in primary ...
L. MENGATO, E. DRAGHI, P. G. ANDREIS, ARMATO, Ubaldo   +3 more
core  

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Protocol to identify the signaling network of nucleotide second messengers in Shigella sonnei

STAR Protocols
Summary: Here, we present a protocol to detect the signaling network composed of cyclic AMP (cAMP) and cyclic di-GMP (c-di-GMP) signaling systems in Shigella sonnei.
Binbin Cui, Xiayu Chen, Mingfang Wang, Yinyue Deng   +3 more
doaj   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Yc-1 Potentiates Nitric Oxide-Induced Relaxation in Guinea-Pig Trachea

, 2009
1 The effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1- benzylindazole) on tension, levels of cyclic GMP and cyclic AMP were investigated in guinea-pig trachea.
鄧哲明, Hwang, Tsong-Long; Wu, Chin-Chung; Teng, Che-Ming   +1 more
core  

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messengers Cyclic di-GMP and Cyclic AMP-GMP

, 2016
Cyclic dinucleotides are an important class of signaling molecules that regulate a wide variety of pathogenic responses in bacteria, but tools for monitoring their regulation in vivo are lacking.
Colleen A. Kellenberger (1340292), Jade Sales-Lee (761232), Stephen C. Wilson (1974652), Ming C. Hammond (761236)   +3 more
core   +1 more source

Cyclic GMP and cyclic GMP phosphodiesterase in the cell cycle of Tetrahymena pyriformis [PDF]

FEBS Letters, 1976
Graves, M.G., Dickinson, J.R., Swoboda, B.E.P.   +2 more
openaire   +2 more sources

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect

, 1977
Modifications in the cyclic nucleotide systems favoring the expression of cyclic GMP effects were found to occur in the transplanted fast-growing Morris hepatoma 3924A.
Shoji, Mamoru, Kuo, J.F, Morris, Harold P, Davis, Craig W, Brackett, Nancy L   +4 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source