Results 111 to 120 of about 611,110 (302)

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption

Microbial Biotechnology
The second messenger bis‐(3′ → 5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, Pablo I. Nikel, Andrea M. Smania   +5 more
doaj   +1 more source

Topology‐Driven X‐Shaped DNA as a cGAS Stimulator to Promote Dendritic Cell Activation and Antitumor Vaccine Efficacy

Advanced Science, EarlyView.
X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li, Xuan Wang, Dali Wei, Zhejie Chen, Ziyi Wang, Qing Yu, Yu Yang, Shengpeng Wang   +7 more
wiley   +1 more source

Cyclic GMP and cyclic GMP phosphodiesterase in the cell cycle of Tetrahymena pyriformis [PDF]

FEBS Letters, 1976
Graves, M.G., Dickinson, J.R., Swoboda, B.E.P.   +2 more
openaire   +2 more sources

Hypoxic Preconditioning Restores NK Cell Metabolic Fitness by Attenuating MAPK Signaling to Potentiate Antitumor Immunity in Lung Cancer

Advanced Science, EarlyView.
Solid tumor hypoxia severely compromises natural killer cell function. This study demonstrates that hypoxic preconditioning preserves NK cell antitumor activity by limiting excessive stress ‐MAPK signaling and promoting mitochondrial metabolic fitness.
Dian Zhuang, Xiaoyue Zhu, Na Wang, Qianqian Liu, Lihua Chen, Yanzhuo Ye, Lingrui Shang, Shasha Huang, Cong Ma, Wei Kevin Zhang, Tao Xu, Jiaqi Sun, Huisheng Liu   +12 more
wiley   +1 more source

A novel cyclic GMP-lowering agent, LY83583, blocks carbachol-indiiced cyclic GMP elevation in rabbit atrial strips without blocking the negative inotropic effects of carbachol

, 1985
A novel cyclic GMP-lowering agent, LY83583(6-anilino-5,8-quinolinedkme), was used to investigate the possibility that increases in myocardial cyclic GMP levels are responsible for the negative inotropic effects of cholinergic agonists. Concentrations of
Jack Diamond, Evelyn B. Chu
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Synergistic growth stimulation of Conn's adenoma cells by cycli AMP and GMP

, 1980
Preliminary evidence indicates that cycli AMP and cyclic GMP elicit a synergistic growth stimulation of Conn's adenoma ...
L. MENGATO, E. DRAGHI, P. G. ANDREIS, ARMATO, Ubaldo   +3 more
core  

Unraveling ovarian histology: The key morphological aspects that spur the development of the Fossa ovarii in equine

The Anatomical Record, EarlyView.
Abstract The equine ovary exhibits unique structural and developmental features that distinguish it from those of other domestic species, including the presence of an ovulation fossa and an inversion of cortical and medullary layers. This study aimed to investigate the morphostructural development of the equine fetal ovary, with particular emphasis on ...
Laura Ver Goltz, Silvio Pires Gomes, Bruno Cesar Schimming, Fabio Cesar Magioli Abdala, Maria Angélica Miglino, Tais Harumi de Castro Sasahara   +5 more
wiley   +1 more source

Negative regulation of cyclic-AMP levels by carbamylcholine in dog thyroid is not mediated by cyclic-GMP

, 1985
Carbamylcholine, through calcium, enhances cyclic-GMP accumulation and depresses cyclic-AMP accumulation in TSH stimulated dog thyroid. The results presented show that compounds which can be transformed to nitric oxide increase cyclic-GMP accumulation in
Dumont, Jacques Emile, Gervy Decoster, Christine, C. Decoster, J.E. Dumont   +3 more
core   +1 more source