Results 251 to 260 of about 72,449 (334)

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase [PDF]

, 1992
Nikolai O. Artemyev, Heidi E. Hamm
openalex   +1 more source

Dynamic Thermal Modelling for Core‐Type High‐Frequency Transformers Based on Air‐Solid Surface Nusselt Number Calibration

High Voltage, EarlyView.
ABSTRACT Quickly and accurately obtaining the internal temperature distribution of a transformer plays a key role in predicting its operating conditions and simplifying the maintenance process. A reasonable equivalent thermal circuit model is a relatively reliable method of obtaining the internal temperature distribution.
Lujia Wang, Qiao Liang, Mengdi Yang, Hailong Zhang, Ting Chen, Chenliang Ji, Jianwen Zhang   +6 more
wiley   +1 more source

Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.

, 1983
T Yamamoto, S Yamamoto, James C. Osborne, Vincent C. Manganiello, M Vaughan, Hisashi Hidaka   +5 more
openalex   +1 more source

Subclasses of cyclic GMP-specific phosphodiesterase and their role in regulating the effects of atrial natriuretic factor. [PDF]

, 1990
Ronald E. Weishaar, Dianne Kobylarz-Singer, Joan A. Keiser, Stephen J. Haleen, Terry C. Major, S. T. Rapundalo, Janet T. Peterson, Robert L. Panek   +7 more
openalex   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Nitric oxide-cyclic GMP role in Ang II induced hyperpolarization in bovine aortic endothelium cell line (BAE-1). [PDF]

Cytotechnology
Mohammed CM, Al-Habib OAM.
europepmc   +1 more source

Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro

, 1986
Robert M. Rapoport, Robert Ginsburg, Scott A. Waldman, Ferid Murad   +3 more
openalex   +1 more source

Co‐operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity

British Journal of Haematology, EarlyView.
A proposed model of Setd2 deficiency and KrasG12D/+ mutation synergism in the pathogenesis of juvenile myelomonocytic leukaemia (JMML). KrasG12D/+ mutation instigates constitutive activation of the RAS‐ERK1/2 signalling pathway, and Setd2 ablation in the KrasG12D/+ mutant background further hyperactivates the RAS‐ERK1/2 signalling pathway, leading to ...
Gustave Munyurangabo, Linlin Zhang, Ying Zhou, Peihua Zhang, Xiao Yu, Dou Qu, Dan Yang, Xiaomin Ren, Hongwei Liu, Yonghong Wu, Guangyao Kong, Yi Yang   +11 more
wiley   +1 more source

Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis. [PDF]

Cell Mol Biol Lett
Peng Y, Yang Y, Li Y, Shi T, Xu N, Liu R, Luan Y, Yao Y, Yin C.   +8 more
europepmc   +1 more source