Results 71 to 80 of about 72,449 (334)

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Label‐Free FET Based Biosensor for Detection of Engineered CAR T‐Cells at Single Cell Resolution

Advanced Sensor Research, EarlyView.
A silicon nanowire field‐effect transistor (SiNW FET) biosensor that allows for label‐free, real‐time detection and quantification of engineered Chimeric Antigen Receptor (CAR) T‐cells at single‐cell resolution is presented. By mimicking the CAR‐specific antigen interface, the platform provides highly selective analysis of individual cell surface ...
Trang Anh Nguyen‐Le, Isli Cela, Anja Feldmann, Chang‐Ki Baek, Michael Bachmann, Larysa Baraban   +5 more
wiley   +1 more source

Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]

, 2016
Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic, A Rico, A Shevchenko, A Zhang, AJ Spiers, Alexandra M. Howat, BL Schneider, BR Borlee, BR Kulasekara, C Lamb, C Pesavento, C Reimmann, CD Boyd, Christopher S Hayes, CO Dimkpa, D Haas, D Yu, DC Naseby, DN Rodriguez-Navarro, E Barahona, E Barahona, E Burrowes, E Trampari, Eleftheria Trampari, F Harrison, G Desnoyers, G Mulley, G Zhao, Gerhard Saalbach, GL Winsor, H Kulasakara, I Kuiper, I Moll, J Boch, J Timmermans, JA Moscoso, JA Vizcaino, Jacob G. Malone, JG Malone, JH Miller, JT Greenberg, JW Hickman, K Kino, K Lapouge, K Maki, K Matsumoto, K Potrykus, KH Choi, KK Swinger, Lucia Grenga, M Christen, M Frederix, M Gao, M Jozefczak, M Lindeberg, M Starkey, MC Whalen, MH Rau, MV Nesterchuk, MW Silby, NM Wilf, P Sobrero, R Hengge, R Little, Richard H. Little, RP Ryan, S Heeb, S Lindenberg, Sebastian Pfeilmeier, SL Kuchma, T Afonyushkin, T Moller, T Morita, TS Walker, TT Hoang, TW Lynch, U Jenal, UA Bommer, VK Ramachandran, WC Winkler, WK Kang, WM Konyecsni, XF Xin, Y Irie   +83 more
core   +3 more sources

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

The Heme-Based Oxygen-Sensor Phosphodiesterase Ec DOS (DosP): Structure-Function Relationships

Biosensors, 2013
Escherichia coli Direct Oxygen Sensor (Ec DOS, also known as Ec DosP) is a heme-based O2-sensing phosphodiesterase from Escherichia coli that catalyzes the conversion of cyclic-di-GMP to linear di-GMP.
Toru Shimizu
doaj   +1 more source

Furosemide Enhances the Release of Endothelial Kinsis, Nitric Oxide and Prostacyclin [PDF]

, 1994
Despite a wealth of data, the mechanism of the direct dilator effect of furosemide on the systemic arterial and venous systems is far from being satisfactorily understood.
Fink, Edwin, Hropot, Max, Linz, Wolfgang, Schölkens, Bernward A., Wiemer, Gabriele, Wohlfart, Paulus   +5 more
core  

c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae. [PDF]

, 2020
Biofilm formation by Vibrio cholerae facilitates environmental persistence, and hyperinfectivity within the host. Biofilm formation is regulated by 3',5'-cyclic diguanylate (c-di-GMP) and requires production of the type IV mannose-sensitive hemagglutinin
Biais, Nicolas, Brun, Yves V, Campos-Gomez, Javier, Chlebek, Jennifer L, Crair, Benjamin, Dalia, Ankur B, Ellison, Courtney K, Farhat, Ali M, Floyd, Kyle A, Hughes, Hannah Q, Hwan Park, Jin, Lee, Calvin K, Liu, Jun, Lomba, Charles J, Nametalla, Mahmoud, Valentine, Aneesa, Wong, Gerard CL, Wu, Daniel C, Xian, Wujing, Yildiz, Fitnat H, Zhu, Shiwei   +20 more
core   +2 more sources

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

The PAS domain-containing histidine kinase RpfS is a second sensor for the diffusible signal factor of Xanthomonas campestris [PDF]

, 2014
Summary: A cell-cell signalling system mediated by the fatty acid signal DSF controls the virulence of Xanthomonas campestris pv. campestris (Xcc) to plants. The synthesis and recognition of the DSF signal depends upon different Rpf proteins.
Allan, John H., An, Shi-Qi, Dow, J. Maxwell, Febrer, Melanie, McCarthy, Yvonne, Ryan, Robert P.   +5 more
core   +2 more sources