The Sunrise of Tertiary Lymphoid Structures in Cancer
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort+3 more
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Hirudin promotes proliferation and osteogenic differentiation of HBMSCs via activation of cyclic guanosine monophosphate (cGMP)/protein kinase-G (PKG) signaling pathway. [PDF]
Cao S+6 more
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Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats. [PDF]
A.H. Cohen+6 more
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Chunxi Yang+12 more
semanticscholar +1 more source
Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems and often occurring alongside the aging process.
Zhongwen Qi+6 more
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Shunxin decoction improves diastolic function in rats with heart failure with preserved ejection fraction induced by abdominal aorta constriction through cyclic guanosine monophosphate-dependent protein kinase Signaling Pathway. [PDF]
Jiaying Z+14 more
europepmc +1 more source
Nitric oxide/cyclic guanosine monophosphate pathway in the peripheral and central auditory system of the rat [PDF]
James D. Fessenden+3 more
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First report on 7‐membered cyclic nucleotides, 2',3'‐cNTDPs, obtained from all‐natural free ribonucleosides in robust, step‐economic synthesis involving instantaneous and regio‐selective reaction. DFT calculations confirmed the feasibility of 7‐membered cyclic nucleotide formation and deciphered the basis for regioselectivity.
Sveta Liberman+4 more
wiley +1 more source
Ajuga bracteosa Exerts Antihypertensive Activity in l-NAME-Induced Hypertension Possibly through Modulation of Oxidative Stress, Proinflammatory Cytokines, and the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway. [PDF]
Shaukat B+7 more
europepmc +1 more source