Results 11 to 20 of about 62,325 (154)

Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

open access: yesFrontiers in Microbiology, 2021
Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun   +4 more
doaj   +1 more source

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

open access: yesNature Communications, 2021
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair ...
Daipayan Banerjee   +13 more
doaj   +1 more source

Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context

open access: yesiScience, 2023
Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet.
Judit E. Šponer   +6 more
doaj   +1 more source

Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging

open access: yesCommunications Biology, 2022
A red fluorescent protein-based indicator of cyclic guanosine 3′, 5′-monophosphate (cGMP) allows for multi-colour imaging and optogenetic applications while monitoring cGMP activity in cells.
Mai Takizawa   +7 more
doaj   +1 more source

Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate

open access: yesFrontiers in Microbiology, 2021
Many bacterial species in nature possess the ability to transition into a sessile lifestyle and aggregate into cohesive colonies, known as biofilms.
Myles B. Poulin, Laura L. Kuperman
doaj   +1 more source

Vericiguat: A New Hope for Heart Failure Patients

open access: yesCardiovascular Therapeutics, 2022
Heart failure with reduced ejection fraction (HFrEF) is the inability of the heart to adequately contract or eject blood. This heart is unable to produce adequate cardiac output to perfuse vital tissues.
Raquel Chiles, Rami A. Al-Horani
doaj   +1 more source

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

open access: yes, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,   +8 more
core   +2 more sources

Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]

open access: yes, 2001
Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz   +22 more
core   +2 more sources

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

open access: yesFrontiers in Pharmacology, 2022
Phosphodiesterase-1 (PDE1) is a versatile enzyme that has surprisingly received considerable attention as a possible therapeutic target in Alzheimer’s disease (AD) because it maintains the homeostasis of 3ʹ,5ʹ-cyclic adenosine monophosphate (cAMP) and 3ʹ,
Nazir Ahmad   +5 more
doaj   +1 more source

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

open access: yesJournal of Cardiovascular Development and Disease, 2018
Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains.
Nikoleta Pavlaki, Viacheslav O. Nikolaev
doaj   +1 more source

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