Results 71 to 80 of about 62,432 (257)

Cyclic Guanosine 3′ ,5′-Monophosphate and Gallbladder Contraction

Gastroenterology, 1974
Cholecystokinin, acetylcholine, and oxymetazoline stimulated guanylyl cyclase activity in rabbit gallbladder. Cholecystokinin and acetylcholine also raised the intracellular levels of cyclic guanosine monophosphate in that tissue. The rise in intracellular cyclic guanosine monophosphate preceded and could mediate both the cholecystokinin- and ...
openaire   +2 more sources

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Analysis of substrate specificity and kinetics of cyclic nucleotide phosphodiesterases with N'-methylanthraniloyl-substituted purine and pyrimidine 3',5'-cyclic nucleotides by fluorescence spectrometry.

PLoS ONE, 2013
As second messengers, the cyclic purine nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) play an essential role in intracellular signaling.
Daniel Reinecke, Frank Schwede, Hans-Gottfried Genieser, Roland Seifert   +3 more
doaj   +1 more source

Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]

, 2018
Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita, Parija, Subas Chandra, Rattan, Satish, Suklabaidya, Sujit   +3 more
core   +2 more sources

Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis [PDF]

Hepatology, 2014
Abstract The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors.
Eloi R. Verrier, Michaela U. Gack, Thomas F. Baumert, J W Schoggins, D A MacDuff, N Imanaka, M D Gainey, B Shrestha, J L Eitson   +8 more
openaire   +2 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Mouse versus Rat: Profound Differences in Meiotic Regulation at the Level of the Isolated Oocyte [PDF]

, 2011
Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed ...
Biggers, Brannstrom, Chen, Chen, Cho, Dekel, Dekel, Dekel, Dekel, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Eppig, Fagbohun, Fagbohun, Han, Hubbard, LaRosa, LaRosa, Larsen, Magnusson, Makris, Masciarelli, Mouse Genome Sequencing Consortium, Mullins, Norris, Norris, Norris, Racowsky, Rat Genome Sequencing Project Consortium, Ratner, Ratner, Reizel, Richard, Romero, Schultz, Sela-Abramovich, Sela-Abramovich, Sela-Abramovich, Shitsukawa, Tornell, Tornell, Tornell, Tornell, Tornell, Tsafriri, Tsafriri, Vaccari, Vivarelli, Zeilmaker, Zhang, Zhang, Zhang, Zhao   +61 more
core   +2 more sources

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors

Biosensors
Phosphodiesterases (PDEs), a superfamily of enzymes that hydrolyze cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), are recognized as a therapeutic target for various diseases.
Chunhua Gao, Zhe Wang, Xiaojing Liu, Rongzhen Sun, Shengyao Ma, Zongchen Ma, Qi Wang, Guoqiang Li, Han-Ting Zhang   +8 more
doaj   +1 more source