Results 91 to 100 of about 495,326 (197)
Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]
, 2009 The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
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, 2023 Soft tissue defects or pathologies frequently necessitate the use of biomaterials that provide the volume required for subsequent vascularization and tissue formation as autrografts are not always a feasible alternative.
Maria Merino-Gómez +17 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
, 2022 Effect of maternal and prepubertal codeine use, and prepubertal arginine use on serum nitric oxide (NO) and penile cyclic guanosine monophosphate (cGMP).
Ayodeji F. Ajayi (13783267) +2 more
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Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Effect of BHE on the involvement of the cyclic guanosine monophosphate (cGMP) pathway.
, 2015 The data represent the mean ± SEM (n = 10).MB = Methylene blue.*p < 0.01 compared with the control group;ap < 0.01 compared with the BHE 100 group (ANOVA, followed by the Dunnett's test).Effect of BHE on the involvement of the cyclic guanosine ...
Jinlong Xu (689841) +6 more
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Emerging roles in plant biotechnology for the second messenger cGMP - guanosine 3’, 5’-cyclic monophosphate [PDF]
, 2010 Second messengers are small transient molecules that transmit and/or modulate environmental or hormonal signals linking them to complex and often systemic physiological responses. Recent reports have renewed interest in the second messenger guanosine 3’,
Meier, S, Gehring, C
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British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
wiley +1 more source
The efficient synthesis and purification of 2′3’- cGAMP from Escherichia coli
Frontiers in MicrobiologyAgonists of the stimulator of interferon genes (STING) pathway are being explored as potential immunotherapeutics for the treatment of cancer and as vaccine adjuvants for infectious diseases.
Rohan Kulkarni +5 more
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Research progress of phosphodiesterase 5 in heart failure [PDF]
Jichu yixue yu linchuangPhosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and
YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei
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