Results 131 to 140 of about 3,700,789 (338)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Cyclic uniaxial and biaxial hardening of type 304 stainless steel modeled by the viscoplasticity theory based on overstress [PDF]
The isotropic theory of viscoplasticity based on overstress does not use a yield surface or a loading and unloading criterion. The inelastic strain rate depends on overstress, the difference between the stress and the equilibrium stress, and is assumed ...
Krempl, Erhard, Yao, David
core +1 more source
, 1973 Tester investigates fundamental factors affecting cyclic life and sealing performance of valve seats and poppets. Tester provides for varying impact loading of poppet against seat and rate of cycling, and controls amount and type of relative motion ...
Tellier, G. F.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Meitan xuebaoDuring deep coal mining processes, periodic mining disturbances cause the neighboring coal strata to bear the effects of cyclic loading and unloading, making it essential to study the mechanical responses and macro-micro failure characteristics of the ...
Kai WANG +5 more
doaj +1 more source
Comparison of different modelling strategies for the representation of non linear response of RC columns subjected to biaxial loading [PDF]
, 2011 Aiming at studying the performance of different non-linear modelling strategies for RC columns subjected to axial load and cyclic biaxial horizontal loading, several analyses were developed using the computer code SeismoStruct.
Arêde, A. +3 more
core
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
A finite element analysis of fatigue crack closure [PDF]
Experiments have shown that fatigue cracks close at positive loads during constant-amplitude load cycling. The crack-closure phenomenon is caused by residual plastic deformations remaining in the wake of an advancing crack tip.
Newman, J. C., Jr.
core +1 more source