Results 111 to 120 of about 375,823 (310)

Life prediction of materials exposed to monotonic and cyclic loading: A technology survey and bibliography [PDF]

, 1975
Announced survey directs attention toward low cycle fatigue and thermal fatigue experienced at elevated temperatures equivalent to those found in hot end of gas turbine engine.
Carpenter, J. L., Jr., Mandel, G., Moya, N., Stuhrke, W. F.   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Calculation model for lateral response of piles considering the characteristics of sand convection under asymmetric cyclic loading

Applied Ocean Research
Pile foundations supporting wind turbines and offshore platforms are always subjected to asymmetric lateral cyclic loads from wind and waves. To calculate the lateral response of the pile in sand under asymmetric cyclic loading, this paper proposes a p−y
Fanhuan Zeng, Chong Jiang
doaj   +1 more source

Experimental investigation of pretensioned bolts under cyclic loading: Damage assessment using acoustic emission

International Journal of Distributed Sensor Networks, 2019
Understanding the acoustic emission effects on bolts under cyclic loading is of great significance for the support of roadways. The presented research focuses on the acoustic emission characteristics of bolts under cyclic loading.
Tieliang An, Xigui Zheng, Dengxing Zhu, Deyu Qian, Yu Guo, Juncai Cao   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Inelastic Model for Cyclic Biaxial Loading of Reinforced Concrete [PDF]

, 1974
National Science Foundation Research Grant GI ...
Darwin, D., Pecknold, D.A.W.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effective Stress-Based Numerical Method for Predicting Large-Diameter Monopile Response to Various Lateral Cyclic Loadings

Journal of Marine Science and Engineering
Extreme marine environmental cyclic loading significantly affects the serviceability of monopiles applied for the foundation of offshore wind turbines (OWTs).
Jichao Lei, Kehua Leng, Wei Xu, Lixian Wang, Yu Hu, Zhen Liu   +5 more
doaj   +1 more source

Microfracture in high temperature metal matrix laminates [PDF]

Computational simulation procedures are described to evaluate the composite microfracture behavior, establish the hierarchy/sequence of fracture modes, and the influence of compliant layers and partial debonding on composite properties and microfracture ...
Chamis, Christos C., Gotsis, Pascal K., Mital, Subodh K.   +2 more
core   +1 more source