Results 111 to 120 of about 4,001,407 (359)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Effect of Cyclic Loading on the Elasticity of Beech Solid and Laminated Wood

BioResources, 2014
This article deals with the determination of the cyclic loading effect on the elastic modulus (Em) of beech solid and laminated wood at various thicknesses while bent in the radial direction.
Milan Gaff, Jozef Gáborík
doaj   +1 more source

Effects of cyclic loading on the shear behaviour of infilled rock joints under constant normal stiffness conditions

, 2014
The variation of the shear strength of infilled rock joints under cyclic loading and constant normal stiffness conditions is studied. To simulate the joints, triangular asperities inclined at angles of 9.5° and 18.5° to the shear movement were cast using
Aziz, Naj, Nemcik, Jan, Mirzaghorbanali, Ali   +2 more
core   +1 more source

Comparison between defects and micro-notches in multiaxial fatigue – The size effect and the gradient effect [PDF]

, 2009
Lien vers la version éditeur: http://www.sciencedirect.com/science/article/pii/S0142112308002156This paper attempts to improve the understanding of the multiaxial high cycle fatigue response of micro sized stress concentrations or notches of different ...
MOREL, Franck, NADOT, Yves, MOREL, Anne
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Behaviour of monopile-gravity-shallow bucket hybrid foundation for offshore wind turbine under cyclic load in sandy soil

Applied Ocean Research
This paper investigates the behavior of a monopile-gravity-shallow bucket (MGB) hybrid foundation for offshore wind turbines (OWTs) under cyclic loading conditions. The study aims to understand the long-term performance of the hybrid foundation, focusing
Xinyao Li, Yi Tan, Yifei Sun, Min Zhang, Wei Duan, Zean Xiao   +5 more
doaj   +1 more source

Cyclic response of RC beam-column joints reinforced with plain bars: an experimental testing campaign

, 2012
Existing reinforced concrete (RC) buildings constructed until the mid-70’s, with plain reinforcing bars, are expected to behave poorly when subjected to earthquake actions.
Costa, A., Melo, J., Varum, H., Rossetto, T.   +3 more
core  

Cyclic lateral loading of monopile foundations in cohesionless soils

, 2015
The monopile is the dominant foundation type for offshore wind turbines, with current design guidance based on knowledge transferred from the oil and gas industry. Whilst there are some similarities between wind turbine and oil and gas pile design, there
Christelle Nadine Abadie, Abadie, Christelle Nadine   +1 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source