Results 101 to 110 of about 375,823 (310)

Development of rock creep test system considering dynamic-static and ultralow-frequency cyclic loading

Journal of Rock Mechanics and Geotechnical Engineering
This paper presents an ultralow-frequency cyclic loading creep test system for rock salt. The system comprises five subsystems: a cyclic load generation system, a triaxial pressure chamber, a pressure and deformation monitoring system, a signal ...
Yinping Li, Zhikai Dong, Xilin Shi, Haoran Li, Cuiyao Zhuo, Yuanxi Liu, Xiangsheng Chen, Si Huang, Weigang Zhao, Yaodong Qi   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Elastic-Plastic Finite Element Analysis of Fatigue Crack Growth in Mode 1 and Mode 2 Conditions [PDF]

Presented is an alternate cost-efficient and accurate elastic-plastic finite element procedure to analyze fatigue crack closure and its effects under general spectrum loading. Both Modes 1 and 2 type cycling loadings are considered.
Atluri, S. N., Nakagaki, M.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Behaviour of monopile-gravity-shallow bucket hybrid foundation for offshore wind turbine under cyclic load in sandy soil

Applied Ocean Research
This paper investigates the behavior of a monopile-gravity-shallow bucket (MGB) hybrid foundation for offshore wind turbines (OWTs) under cyclic loading conditions. The study aims to understand the long-term performance of the hybrid foundation, focusing
Xinyao Li, Yi Tan, Yifei Sun, Min Zhang, Wei Duan, Zean Xiao   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Modeling and Simulation of the Effects of Cyclic Loading on Articular Cartilage Lesion Formation

, 2013
We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al.
Ayati, Bruce P., Brouillete, Marc J., Graham, Jason M., Martin, James A., Ramakrishnan, Prem S., Wang, Xiayi   +5 more
core  

Effect of Structural Anisotropy on Deformation Properties of Granite under Cyclic Loading [PDF]

, 1997
The effects of structural anisotropy on the deformation properties of granite under cyclic loading have not been clarified. In this paper, four types of granite specimens are prepared with an angle θ of the structural anisotropic plane to the loading ...
Kusumi Harushige, Mine Yukihisa, Nishida Kazuhiko, 峰 之久, 楠見 晴重, 西田 一彦   +5 more
core   +1 more source

Asymptotic homogenisation in strength and fatigue durability analysis of composites [PDF]

This is the post-print version of the Article. Copyright @ 2003 Kluwer Academic Publishers.Asymptotic homogenisation technique and two-scale convergence is used for analysis of macro-strength and fatigue durability of composites with a periodic structure
A. N. Kolmogorov, D. Cioranescu, G. Allaire, N. Bakhvalov, S. E. Mikhailov, V. A. Trenogin   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source