Results 101 to 110 of about 4,001,407 (359)

The Influence of Cyclic Loading on the Mechanical Properties of Well Cement

Energies
The cyclic loading generated by injection and production operations in underground gas storage facilities can lead to fatigue damage to cement sheaths and compromise the integrity of wellbores.
Zhen Zhang, Zhongtao Yuan, Sutao Ye, Yang Li, Lvchao Yang, Xueyu Pang, Kaihe Lv, Jinsheng Sun   +7 more
doaj   +1 more source

Structural integrity assessment of superheater outlet penetration tubeplate

, 2009
In recent years, the Linear Matching Method (LMM) has been well developed for the integrity assessment of the component subjected to cyclic thermal and mechanical loads.
Haofeng Chen, Chen, Haofeng, Ponter, Alan R.S., Alan R.S. Ponter   +3 more
core   +1 more source

Properties evolution of flax/epoxy composites under fatigue loading [PDF]

, 2014
The tension–tension fatigue behaviour of flax fibre reinforced epoxy matrix composites have been investigated for specimens having [0]12, [90]12, [0/90]3S and [±45]3S lay-ups.
GNING, Papa-Birame, LIANG, Shaoxiong, GUILLAUMAT, Laurent   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Analysis of permeability evolution law of gas-bearing coal under cyclic loading condition

Meitan kexue jishu
In order to explore the permeability evolution law of gas-bearing coal under different cyclic loading and unloading conditions, raw coal samples were taken as the research object, and cyclic loading-unloading experiments of gas-bearing coal were designed
Dengke WANG, Haohang FENG, Jianping WEI, Xu CHEN, Zhigang JIANG, Xiuzhu YUAN, Yun BAI, Tanggen CAO, Wenchao XIONG   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A New Method for Predicting Dynamic Pile Head Stiffness Considering Pile–Soil Relative Stiffness Under Long-Term Cyclic Loading Conditions

Buildings
Under long-term horizontal cyclic loading, the evolution characteristics of the loading and unloading stiffness of piles are an important representation of pile–soil interaction.
Jie Chen, Jiaqing Shu, Shuang Xi, Xiaoqing Gu, Mingxing Zhu, Xiaojuan Li   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development of rock creep test system considering dynamic-static and ultralow-frequency cyclic loading

Journal of Rock Mechanics and Geotechnical Engineering
This paper presents an ultralow-frequency cyclic loading creep test system for rock salt. The system comprises five subsystems: a cyclic load generation system, a triaxial pressure chamber, a pressure and deformation monitoring system, a signal ...
Yinping Li, Zhikai Dong, Xilin Shi, Haoran Li, Cuiyao Zhuo, Yuanxi Liu, Xiangsheng Chen, Si Huang, Weigang Zhao, Yaodong Qi   +9 more
doaj   +1 more source

On shakedown, ratchet and limit analysis of defective pipeline

, 2011
In this study, the limit load, shakedown and ratchet limit of a defective pipeline subjected to constant internal pressure and a cyclic thermal gradient are analyzed.
Ure, James Michael, James Ure, Haofeng Chen, Chen, Haofeng, Li, Tianbai, Tianbai Li, Weihang Chen, Chen, Weihang   +7 more
core   +1 more source