Results 131 to 140 of about 4,001,407 (359)
, 2012 The information available in the literature about the cyclic behaviour of reinforced concrete elements with plain reinforcing bars is scarce. As a consequence, the influence of bar slippage in elements with plain bars is not yet comprehensively ...
Costa, A. +3 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Applied SciencesThe fracture behavior of Beishan granite is a critical scientific basis for evaluating and ensuring the long-term safety of geological repositories for high-level radioactive waste under extreme thermal–mechanical conditions.
Gen Li +4 more
doaj +1 more source
The Influence of Subgrade Subsidence on Train Track Dynamic Interaction
, 2012 Railways 2012 The First International Conference on Railway Technology: Research, Development and Maintenance Las Palmas de Gran Canaria, Spain 18-20 April 2012This paper reports results from a numerical model to calculate subgrade settlement in ...
E.J. OBrien +5 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Linear matching method for design limits in plasticity
, 2010 In this paper a state-of-the-art numerical method is discussed for the evaluation of the shakedown and ratchet limits for an elastic-perfectly plastic body subjected to cyclic thermal and mechanical load history. The limit load or collapse load, i.e. the
Chen, Haofeng
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