Results 201 to 210 of about 242,009 (329)

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

An atypical GdpP enzyme linking cyclic nucleotide metabolism to osmotic tolerance and gene regulation in Mycoplasma bovis. [PDF]

Front Microbiol, 2023
Zhu X, Baranowski E, Hao Z, Li X, Zhao G, Dong Y, Chen Y, Hu C, Chen H, Citti C, Wang A, Guo A.   +11 more
europepmc   +1 more source

Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain

, 2016
Yu‐Chuan Wang, Ko‐Hsin Chin, Zhi‐Le Tu, Jin He, Christopher J. Jones, David Zamorano‐Sánchez, Fitnat H. Yildiz, Michael Y. Galperin, Shan‐Ho Chou   +8 more
openalex   +1 more source

Cyclic Nucleotide (cAMP and cGMP) Assays and Capture ELISA for Quantitative Analysis of Plasmodium falciparum Blood-stage Egress [PDF]

, 2014
Fiona Hackett, Christine Collins, Malcolm Strath, Michael J. Blackman   +3 more
openalex   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A? [PDF]

Int J Mol Sci, 2023
Zheng Y, Schroeder S, Kanev GK, Botros SS, William S, Sabra AA, Maes L, Caljon G, Gil C, Martinez A, Salado IG, Augustyns K, Edink E, Sijm M, de Heuvel E, de Esch IJP, van der Meer T, Siderius M, Sterk GJ, Brown D, Leurs R.   +20 more
europepmc   +1 more source

The Role of Cyclic Nucleotides in Axon Guidance

, 2007
Michael Piper, Francis van Horck, Christine E. Holt   +2 more
openalex   +2 more sources

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

The cyclic nucleotide-gated channels CNGC2 and CNGC4 support systemic wound responses in <i>Arabidopsis thaliana</i>. [PDF]

Front Plant Sci
Johns S, Wiegman E, Bakshi A, Gilroy S.
europepmc   +1 more source

An Expanding Role of 2',3'-Cyclic Nucleotide Monophosphates in Bacteria. [PDF]

ACS Cent Sci, 2022
Vennard C, Sintim HO.
europepmc   +1 more source