Results 221 to 230 of about 242,009 (329)

Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases

, 2003
Ferenc Erdődi, Enikö Kiss, Michael P. Walsh, Bjarki Stefansson, Jing Deng, Masumi Eto, David L. Brautigan, David J. Hartshorne   +7 more
openalex   +2 more sources

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Combination of Autodisplay and Dynamic Pharmacophore Modeling Reveals New Insights into Cyclic Nucleotide Binding in Hyperpolarization-Activated and Cyclic Nucleotide-Gated Ion Channel 4 (HCN4). [PDF]

ACS Pharmacol Transl Sci
Wojciechowski MN, Jokiel J, Kuss H, Bermúdez M, Jose J.   +4 more
europepmc   +1 more source

Cardiac Cyclic Nucleotide Phosphodiesterases: Function, Regulation, and Therapeutic Prospects

, 2012
Walter E. Knight, Yan Chen
openalex   +1 more source

Structural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels [PDF]

, 2013
Sven Schünke, Matthias Stoldt
openalex   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK. [PDF]

Nat Commun
Thon O, Wang Z, Schmidpeter PAM, Nimigean CM.   +3 more
europepmc   +1 more source

KS-504 compounds, novel inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from mollisia ventosa.

, 1989
Satoshi Nakanishi, Katsuhiko Ando, Isao Kawamoto, Toru Yasuzawa, Hiroshi Sano, Hiroshi Kase   +5 more
openalex   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels. [PDF]

J Gen Physiol
Page DA, Ruben PC.
europepmc   +1 more source