Results 251 to 260 of about 102,215 (297)

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

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Cyclic nucleotides

Phytochemistry, 2004
The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and breakdown. Here we describe the significant properties of cyclic nucleotides, also outlining their second messenger ...
Russell P, Newton, Christopher J, Smith
openaire   +2 more sources

Saturation of anti cyclic nucleotides antibodies by endogenous cyclic nucleotides

Biochemical and Biophysical Research Communications, 1979
Abstract Rabbits immunized against cyclic AMP or cyclic GMP produce antibodies which are fully saturated by their respective endogenous cyclic nucleotides. This was proved a) in comparing radioimmunological measurements of cyclic nucleotides in antiserum and the binding site concentration determined by equilibrium dialysis, b) in showing the ...
Michel Delaage, H.L. Cailla, D. Roux
openaire   +3 more sources

Chemistry of Cyclic Nucleotides and Cyclic Nucleotide Analogs

1982
Since the isolation and characterization of cAMP in early 1957, several enzymatic and chemical synthetic procedures have been developed to provide cAMP and various cyclic nucleotide analogs. The synthesis of cAMP and 2′-deoxy-cAMP by bacterial fermentation is of current commercial interest as a low cost source of nucleoside 3′,5′-cyclic phosphates.
G. R. Revankar, R. K. Robins
openaire   +2 more sources

Cyclic Nucleotide Immunohistochemistry

Journal of Histotechnology, 1981
AbstractIt has been reported that cyclic nucleotide immunohistochemistry fails to localize all pools of cyclic nucleotides and to detect the changes in cyclic nucleotide concentration when applied to unfixed brain tissue sections. Losses of cyclic nucleotides during antibody incubations have been demonstrated, but it has not been determined whether ...
Thomas P. Hartz, Ladislav Volicer
openaire   +2 more sources

Cyclic Nucleotides and Neuroblastoma Differentiation

Nucleosides, Nucleotides and Nucleic Acids, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
MESSINA, ELISA, LUPI F, BARILE, Lucio, GIACOMELLO, Alessandro   +3 more
openaire   +4 more sources

Cyclic nucleotides and photoreception

Experimental Eye Research, 1973
Abstract Biochemical evidence indicates that the production of cyclic-AMP by vertebrate rod outer-segments is regulated by illumination. Injection of cyclic nucleotides directly into photoreceptor cells of the invertebrate, Limulus , is without significant physiological effect.
openaire   +3 more sources

Cyclic Nucleotides in Neuromuscular Transmission

Anesthesia & Analgesia, 1981
A review of the research on cyclic nucleotides and neuromuscular transmission suggests that cAMP is involved in the release of transmitter from motor nerve endings. Lipid-soluble derivations of cAMP cause depolarization of unstimulated nerve endings and prolong the after potentials of stimulated nerve endings.
Kenneth L. Dretchen, Frank G. Standaert
openaire   +4 more sources