Results 261 to 270 of about 102,215 (297)
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Cyclic nucleotide phosphodiesterases
Journal of Allergy and Clinical Immunology, 2001Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE) enzymes. Continuing advances in our understanding of the molecular pharmacology of these enzymes has led
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Cyclic nucleotides, cyclic nucleotide phosphodiesterase, and development in Myxococcus xanthus
Canadian Journal of Microbiology, 1978Exogenous cyclic nucleotide phosphodiesterase (PD) accelerated fruiting body (FB) formation and increased territory size of aggregates in Myxococcus xanthus. Both guanosine 3′5′- monophosphate (cGMP) and guanosine 5′-monophosphate (GMP) were antagonistic to the PD effect.
W. J. Dobson, J. Ho, H. D. McCurdy
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Experimental Cell Research, 1979
Abstract Polysphondylium violaceum is shown to produce and excrete cyclic nucleotides and to produce a cell-associated cyclic nucleotide phosphodiesterase(s). The amount of adenosine 3′,5′-cyclic monophosphate (cAMP) excreted by the amebae reaches a maximum during development when aggregation centers are just forming and then falls off rapidly ...
Michael H. Hanna +2 more
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Abstract Polysphondylium violaceum is shown to produce and excrete cyclic nucleotides and to produce a cell-associated cyclic nucleotide phosphodiesterase(s). The amount of adenosine 3′,5′-cyclic monophosphate (cAMP) excreted by the amebae reaches a maximum during development when aggregation centers are just forming and then falls off rapidly ...
Michael H. Hanna +2 more
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Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels
ACS Chemical Biology, 2014Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a central role in the regulation of cardiac and neuronal firing rate, and these channels can be dually activated by membrane hyperpolarization and by binding of cyclic nucleotides. cAMP has been shown to directly bind HCN channels and modulate their activity.
Moller, Stefan +8 more
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Cyclic nucleotides in rheumatoid arthritis
Agents and Actions, 1980Cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5' guanosine monophosphate (cGMP) may influence important regulatory mechanisms in the rheumatoid inflammatory process. It has been claimed that fasting improves the condition of the patient with rheumatoid arthritis (RA).
Olle Lövgren +4 more
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Cyclic nucleotides in experimental glaucoma
Bulletin of Experimental Biology and Medicine, 1988cAMP and cGMP contents were studied in various eye tissues of rabbits with experimental glaucoma induced by chronic intravenous adrenaline administration. Cyclic nucleotide level was measured in the retina, choroid, iris and ciliary body. An increase in the tissue cAMP level was found especially in the iris and ciliary body.
Kashintseva Lt +4 more
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1982
The events taking place intracellularly within the central nervous system when pyrogens, putative neurotransmitters or other pharmacologically active substances raise body temperature during fever are poorly understood. Recognition of cyclic AMP as an intracellular mediator of adrenaline and glucagon-induced activation of hepatic glycolysis (Sutherland
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The events taking place intracellularly within the central nervous system when pyrogens, putative neurotransmitters or other pharmacologically active substances raise body temperature during fever are poorly understood. Recognition of cyclic AMP as an intracellular mediator of adrenaline and glucagon-induced activation of hepatic glycolysis (Sutherland
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Prostaglandins and Cyclic Nucleotides
1982The literature on the interactions of prostaglandins (PGs) and cyclic nucleotides is growing at an ever increasing rate; despite this fact, it is still very difficult to integrate the different and often conflicting reports into a unified picture.
R. Paoletti, S. Nicosia
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Cyclic Nucleotide Phosphodiesterases
2000In multicellular organisms, cell functions are integrated through a large network of signals and homeostatic mechanisms that control the intracellular concentration of second messengers. This is a feature indispensable for the basal functions of the body, as well as for an efficient response to the continuous changes in the environment to which the ...
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Cyclic nucleotides in breast milk
The American Journal of Clinical Nutrition, 1981Adenosine 3':5' monophosphate3 (cAMP) and guanosine 3':5' monophosphate (cGMP) are known to participate in the regulation of proliferation and differentiation, the processes intimately associated with maturation of the neonate. We have therefore examined their content in the physiological nutrient of the mammalian neonate, the mother's milk.
Otakar Koldovsky +2 more
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