Results 31 to 40 of about 1,368,358 (400)
Toxins, 2022 Various bacterial pathogens are producing toxins that target the cyclic Nucleotide Monophosphate (cNMPs) signaling pathways in order to facilitate host colonization.
Marilyne Davi +4 more
doaj +1 more source
Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. [PDF]
, 2017 In Caenorhabditis elegans, the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AWC sensed odors. Prolonged exposure to an AWC sensed odor in the absence of food leads to reversible decreases in the animal's ...
BT Juang +39 more
core +1 more source
Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy
International Journal of Molecular Sciences, 2018 The first step in vision is the absorption of photons by the photopigments in cone and rod photoreceptors. After initial amplification within the phototransduction cascade the signal is translated into an electrical signal by the action of cyclic ...
S. Michalakis, E. Becirovic, M. Biel
semanticscholar +1 more source
Fluorescence Titrations to Determine the Binding Affinity of Cyclic Nucleotides to SthK Ion Channels
Bio-Protocol, 2018 The cyclic-nucleotide modulated ion channel family includes cyclic nucleotide-gated (CNG) and hyperpolarization-activated and cyclic nucleotide-modulated (HCN) channels, which play essential roles in visual and olfactory signaling and the heart ...
Philipp Schmidpeter, Crina Nimigean
doaj +1 more source
Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel
Nature Communications, 2020 SthK, a cyclic nucleotide-gated ion channel from Spirochaeta thermophila activates slowly upon cAMP increase. Here, authors investigate cAMP-induced activation in purified SthK channels using stopped-flow assays and enzymatic catalysis and reveal that ...
Philipp A. M. Schmidpeter +2 more
doaj +1 more source
Kinesin's backsteps under mechanical load [PDF]
, 2009 Kinesins move processively toward the plus end of microtubules by hydrolyzing ATP for each step. From an enzymatic perspective, the mechanism of mechanical motion coupled to the nucleotide chemistry is often well explained using a single-loop cyclic ...
Alberty +71 more
core +1 more source
Cells, 2022 Dopamine and other neurotransmitters have the potential to induce neuroplasticity in the striatum via gene regulation. Dopamine receptor-mediated gene regulation relies on second messenger cascades that involve cyclic nucleotides to relay signaling from ...
Ryan Bonate +6 more
doaj +1 more source
A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]
, 2007 Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Alfredsson, L +8 more
core +2 more sources
Visualization of cyclic nucleotide dynamics in neurons
Frontiers in Cellular Neuroscience, 2014 The second messengers cAMP and cGMP transduce many neuromodulatory signals from hormones and neurotransmitters into specific functional outputs. Their production, degradation and signaling are spatiotemporally regulated to achieve high specificity in ...
Kirill eGorshkov, Jin eZhang
doaj +1 more source
Cells, 2021 Exchange proteins directly activated by cAMP (EPAC1 and EPAC2) are one of the several families of cellular effectors of the prototypical second messenger cAMP.
Zhuofu Ni, Xiaodong Cheng
doaj +1 more source