Results 1 to 10 of about 7,020 (110)

Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles. [PDF]

Proc Natl Acad Sci U S A
Nakashima IF, Zhong H, Nikolaev VO, Owen CM, Yee SP, Jaffe LA, Egbert JR.   +6 more
europepmc   +1 more source

A PDE4 shortform degrader: a first in isoform-specific PDE4 inhibition. [PDF]

FEBS J
Maurice DH.
europepmc   +1 more source

Nitrergic Signaling Mediation of Neurobehavioral Responses to Stress in Zebrafish. [PDF]

J Neurochem
Heymbeeck JAA, de Sousa EB, Lima-Maximino M, Pereira A, Maximino C.   +4 more
europepmc   +1 more source

New Zealand (NZ)'s Medsafe has advised prescribers of the risk of sudden deafness associated with type 5 cyclic nucleotide phosphodiesterase inhibitors,

Reactions Weekly, 2009
openaire   +1 more source

Amlodipine/Selexipag/Type-5-cyclic-nucleotide-phosphodiesterase-inhibitors

Reactions Weekly
openaire   +1 more source

Cyclic Nucleotide Phosphodiesterase Families as Targets to Treat Pulmonary Arterial Hypertension: Beyond PDE5 Inhibitors? [PDF]

Cells
Pulmonary arterial hypertension (PAH) is a fatal disease with no cure. Until recently, most specific therapies for PAH had aimed at enhancing cyclic nucleotide (cAMP and cGMP) pathways, taking advantage of the vasorelaxant and antiproliferative ...
Liting Wang, Rodolphe Fischmeister, Boris Manoury   +2 more
doaj   +2 more sources

Cyclic Nucleotide Phosphodiesterase Type 5 Activity Limits Blood Flow to Hypoperfused Myocardium During Exercise [PDF]

Circulation, 2000
Background—Nitric oxide (NO) causes vasodilation by stimulation of guanylate cyclase in vascular smooth muscle to produce cGMP. The resultant vasodilator effect is regulated by a family of cGMP phosphodiesterases (PDEs). Sildenafil, a selective inhibitor of PDE5 used for treatment of erectile dysfunction, has been found to cause relaxation of isolated ...
J H, Traverse, Y J, Chen, R, Du, R J, Bache   +3 more
openaire   +2 more sources

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]

PLoS ONE, 2016
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil, Loïze Maréchal, Hassan El Hajj, Marie-Ève Tremblay, François J Richard, Pierre Leclerc   +5 more
doaj   +1 more source