Results 81 to 90 of about 130,806 (264)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Electrochemical and spectroelectrochemical investigation of the behaviors of HF, 3-HF, 6-HF, 3,6-DHF on glassy carbon electrode surfaces

Reviews in Analytical Chemistry, 2011
An electrochemical investigation of hydroxyflavone, HF; 3-hydroxyflavone, 3-HF; 6-hydroxyflavone, 6-HF; and 3,6-dihydroxyflavone, 3,6-DHF oxidation on a glassy carbon (GC) electrode was carried out using cyclic voltammetry (CV) and electrochemical ...
Dündar Ezher, Mülazimoğlu Ibrahim Ender, Özkan Erdal   +2 more
doaj   +1 more source

Sensitive and Stable Voltammetric Measurements of Norepinephrine at Ionic Liquid–Carbon Nanotubes Paste Electrodes

International Journal of Electrochemical Science, 2013
The electrochemistry of norepinephrine (NE) was studied by cyclic voltammetry, chronoamperometry and square wave voltammetry (SWV) at a carbon paste electrode modified by multiwall carbon nanotubes (MWNTs) and room-temperature ionic liquid, 1-methyl-3 ...
Mahsa Ansari, Sohrab Kazemi, Mohammad A. Khalilzadeh, Hassan Karimi-Maleh, Mohammad Bagher Pasha Zanousi   +4 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Structural Characterization of the Dimers and Selective Synthesis of the Cyclic Analogues of the Antimicrobial Peptide Cm-p5

Antibiotics
Background/Objectives: Cm-p5 and its cyclic monomeric and dimeric analogues are known for their antifungal, antibacterial, antiviral, and antibiofilm activities.
Fidel E. Morales-Vicente, Luis A. Espinosa, Erbio Díaz-Pico, Ernesto M. Martell, Melaine Gonzalez, Gerardo Ojeda, Luis Javier González, Armando Rodríguez, Hilda E. Garay, Octavio L. Franco, Frank Rosenau, Anselmo J. Otero-González, Ludger Ständker   +12 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Developing advanced CrSi coatings for combatting surface degradation of N-type (Zr,Ti)Ni(Sn,Sb) and P-type (Zr,Ti)Co(Sn,Sb) half Heusler thermoelectric materials

Journal of Materials Research and Technology
In this study, advanced oxidation-protective CrSi coatings were developed and deposited on N-type (Zr,Ti)Ni(Sn,Sb) and P-type (Zr,Ti)Co(Sn,Sb) thermoelectric (TE) materials using an environmentally friendly closed field unbalanced magnetron sputtering ...
Mikdat Gurtaran, Zhenxue Zhang, Xiaoying Li, Hanshan Dong   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Electrochemical oxidation of quercetin in hydro-alcoholic solution

Journal of the Brazilian Chemical Society, 2006
The electrochemistry of quercetin hydro-alcoholic solutions of pH 2.2 to 9.2 was studied by cyclic voltammetry, controlled-potential electrolysis and UV-Vis spectroscopy.
Timbola Ana K., Souza Cristine D. de, Giacomelli Cristiano, Spinelli Almir   +3 more
doaj