Results 131 to 140 of about 2,011,052 (344)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Structure-activity ralationships of cyclic and linear peptide T analogues

, 1993
Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides.
SALVADORI S, MARASTONI M, BALBONI, GIANFRANCO, REALI E, TOMATIS R., SPISANI S, SCARANARI V, TRANIELLO S   +7 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The Contribution of Serum Anti–cyclic Citrullinated Peptide Antibody and Matrix Metalloproteinase-3 in Predicting the Activity of Rheumatoid Arthritis Disease

مجلة كلية الطب, 2017
Background: Rheumatoid arthritis is an autoimmune disease characterized by chronic synovial inflammation. The insufficient immune clearance of the apoptotic cell results into the formation of anti-cyclic citrullinated peptide antibodies which may play a ...
Aida R. Al-Derzi
doaj   +1 more source

A new cyclic peptide from Schnabelia tetradonta

, 2003
A new cyclic octapeptide (schnabepeptide B) was isolated from the aerial part of Schnabelia tetradonta (Sun) C. Y. Wu et C. Chen (Lamiaceae). Its structure was elucidated as cyclo-(NH-Trp-Gly(1)-Leu(1)-Gly(2)-Pro(1)-Pro(2)-Leu(2)-Pro(3)-CO) on the basis ...
Dou, H, Dou, H, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Peng, SL, Ding, LS, Zhou, Y   +4 more
core  

Cyclic D/L Peptide Nanotubes

, 2019
This thesis describes studies of novel cyclic peptide nanomaterials. Specifically, this work explores different approaches to the construction of organic nanotubes using reversible and irreversible binding of peptide building-blocks.
MITCHELL RAMESH SILK (8134095)
core   +1 more source

Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2

Chemistry and Biology, 2014
Summary Languishing antibiotic discovery and flourishing antibiotic resistance have prompted development of alternative untapped sources for antibiotic discovery, including previously uncultured bacteria.
E. Gavrish, C. Sit, Shugeng Cao, Olga Kandror, A. Spoering, Aaron J. Peoples, L. Ling, A. Fetterman, D. Hughes, A. Bissell, H. Torrey, T. Akopian, Andreas Mueller, S. Epstein, A. Goldberg, J. Clardy, K. Lewis   +16 more
semanticscholar   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Prediction of peptide cleavage sites using protein language models and graph neural networks

Scientific Reports
The growing interest in using peptide molecules as therapeutic agents, driven by their high selectivity and efficacy, has become a significant trend in the pharmaceutical industry.
Paula Cifuentes, Ramon Adàlia, Ismael Zamora   +2 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source