Results 221 to 230 of about 1,132,327 (295)

Improving the predictive performance of binding affinities and poses for protein-cyclic peptide complexes through fine-tuned MM/PBSA(GBSA)-based methods. [PDF]

Brief Bioinform
Zhao H, Huang J, Weng G, Jiang D, Hu R, Kang Y, Hou T.   +6 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Quadratic unconstrained binary optimization and constraint programming approaches for lattice-based cyclic peptide docking. [PDF]

Sci Rep
Brubaker JK, Booth KEC, Arakawa A, Furrer F, Ghosh J, Sato T, Katzgraber HG.   +6 more
europepmc   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

A synthetic cyclic peptide for promoting antigen presentation and immune activation. [PDF]

NPJ Vaccines
Zhang J, Madge HYR, Mahmoud A, Lu L, Wang W, Huang W, Koirala P, Gonzalez Cruz JL, Kong WY, Bashiri S, Shalash AO, Hussein WM, Khalil ZG, Wells JW, Toth I, Stephenson RJ.   +15 more
europepmc   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Jejupeptins A and B, Polyketide-Cyclic Peptide Hybrids with Anti-Corticosterone Activity from <i>Streptomyces</i> sp. KCB15JA151. [PDF]

ACS Omega
Jang JP, Roh J, Kim GS, Park J, Hwang GJ, Park B, Lee HW, Takahashi S, Hong YS, Ko SK, Jang JH.   +10 more
europepmc   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Application of Targeted and Suspect Screening Workflows for Cyclic Peptide Cyanotoxin Profiling in Spirulina- and Klamath-Based Food Supplements. [PDF]

Foods
Carbonell-Rozas L, Aparicio-Muriana MM, Romero-González R, Frenich AG, García-Campaña AM, Olmo-Iruela MD.   +5 more
europepmc   +1 more source

cyclicpeptide: a Python package for cyclic peptide drug design. [PDF]

Brief Bioinform
Yang L, Cao S, Liu L, Zhu R, Wu D.
europepmc   +1 more source