Results 101 to 110 of about 825,768 (324)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
On expansive and anti-expansive tree maps [PDF]
Opuscula Mathematica, 2018 With every self-map on the vertex set of a finite tree one can associate the directed graph of a special type which is called the Markov graph. Expansive and anti-expansive tree maps are two extremal classes of maps with respect to the number of loops in
Sergiy Kozerenko
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
THE EMBEDDING OF A CYCLIC PERMUTABLE SUBGROUP IN A FINITE GROUP. II [PDF]
Proceedings of the Edinburgh Mathematical Society, 2003 AbstractIn two previous papers we established the structure of the normal closure of a cyclic permutable subgroup $A$ of a finite group, first when $A$ has odd order and second when $A$ has even order, but with an extra hypothesis that was unnecessary in the odd case.
Cossey, Peter (John) +1 more
openaire +8 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Graphical cyclic permutation groups [PDF]
, 1981 A permutation group H acting on a set X is said to be graphical if there is a graph G such that Γ(G), the automorphism group of G, is identical to H. Characterisation of graphical permutation groups seems to be difficult. Kagno and Chao have shown that the group generated by a single m-cycle is not graphical.
S. P. Mohanty +2 more
openaire +2 more sources
Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes
FEBS Letters, EarlyView.The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji +3 more
wiley +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Nash implementable domains for the Borda count [PDF]
We characterize the preference domains on which the Borda count satisfies Maskin monotonicity. The basic concept is the notion of a "cyclic permutation domain" which arises by fixing one particular ordering of alternatives and including all its cyclic ...
Puppe, Clemens, Tasnádi, Attila
core +1 more source