Results 101 to 110 of about 71,552 (319)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Hidden conformal symmetry in tree-level graviton scattering

open access: yesJournal of High Energy Physics, 2018
We argue that the scattering of gravitons in ordinary Einstein gravity possesses a hidden conformal symmetry at tree level in any number of dimensions. The presence of this conformal symmetry is indicated by the dilaton soft theorem in string theory, and
Florian Loebbert   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Properties of triple error orbits G and their invariants in Bose – Chaudhuri – Hocquenghem codes C7

open access: yesВесці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2019
This work is the further development of the theory of norms of syndromes: the theory of polynomial invariants of G-orbits of errors expands with the group G of automorphisms of binary cyclic BCH codes obtained by joining the degrees of cyclotomic ...
V. A. Lipnitski, A. U. Serada
doaj   +1 more source

Permuting operations on strings: Their permutations and their primes [PDF]

open access: yes, 2009
We study some length-preserving operations on strings that permute the symbol positions in strings. These operations include some well-known examples (reversal, circular or cyclic shift, shuffle, twist, operations induced by the Josephus problem) and ...
Asveld, Peter R.J.
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On Volumes of Permutation Polytopes

open access: yes, 2011
This paper focuses on determining the volumes of permutation polytopes associated to cyclic groups, dihedral groups, groups of automorphisms of tree graphs, and Frobenius groups. We do this through the use of triangulations and the calculation of Ehrhart
Burggraf, Katherine   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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