Results 71 to 80 of about 6,509 (277)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Construction of Cyclically Permutable Codes From Cyclic Codes
Proceedings of The 3rd International Conference on Intelligent Systems and Image Processing 2015, 2015 Cyclically permutable codes (CPCs) are important to communication networks, e.g., multiple access collision channels without feedback and frequency-hopping spread spectrum communication channels. A CPC is a block code of length n such that each codeword has full cyclic order n and all codewords are cyclically distinct.
Ting-Ya Yang +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Permutability graph of cyclic subgroups
, 2015 Let $G$ be a group. \textit{The permutability graph of cyclic subgroups of $G$}, denoted by $ _c(G)$, is a graph with all the proper cyclic subgroups of $G$ as its vertices and two distinct vertices in $ _c(G)$ are adjacent if and only if the corresponding subgroups permute in $G$.
Rajkumar, R., Devi, P.
openaire +2 more sources
Periodic Ordered Permutation Groups and Cyclic Orderings
Journal of Combinatorial Theory, Series B, 1995 It is shown that periodic ordered permutation groups satisfying certain extra conditions are very nearly simple. This is applied to several natural examples, such as the following. (i) If \(z\) denotes the map \(x \mapsto x + 1\) on \(\mathbb{R}\), and \(\text{Diff}(\mathbb{R})\) is the group of diffeomorphisms of \(\mathbb{R}\), then \(C_{\text{Diff}(\
Droste, M., Giraudet, M., Macpherson, D.
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Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
On the $\operatorname{rix}$ statistic and valley-hopping [PDF]
Discrete Mathematics & Theoretical Computer ScienceThis paper studies the relationship between the modified Foata$\unicode{x2013}$Strehl action (a.k.a. valley-hopping)$\unicode{x2014}$a group action on permutations used to demonstrate the $\gamma$-positivity of the Eulerian polynomials$\unicode{x2014 ...
Nadia Lafrenière, Yan Zhuang
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source