Results 31 to 40 of about 41,400 (261)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Phenomenological Modelling of Cyclic Plasticity [PDF]
, 2012 The stress-strain behaviour of metals under a cyclic loading is very miscellaneous and needs an individual approach for different metallic materials. There are many different models that have been developed for the case of cyclic plasticity. This chapter will address only so called phenomenological models, which are based purely on the observed ...
Radim Halama, Josef Sedlk, Michal ofer
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Metals, 2019 This work presents a new isotropic model to describe the cyclic hardening/softening plasticity behavior of metals. The model requires three parameters to be evaluated experimentally.
Jelena Srnec Novak +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2017 This paper presents a finite strain elastoplastic constitutive model incorporating the extended subloading surface concept within the unconventional plasticity framework for cyclic loadings. This is a reformulated and extended version of the small strain
Takuya IGUCHI +3 more
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Measurement and simulation of strain fields around crack tips under mixed-mode fatigue loading [PDF]
Fracture and Structural Integrity, 2015 For various configurations examined in a series of fatigue experiments on thin-walled tubes under tension and torsion, the experimental results – crack path, crack growth life, near crack tip deformations, and crack closure – are measured and compared to
Y. Hos, M. Vormwald, J.L.F. Freire
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