Results 41 to 50 of about 46,614 (307)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Metals, 2019 This work presents a new isotropic model to describe the cyclic hardening/softening plasticity behavior of metals. The model requires three parameters to be evaluated experimentally.
Jelena Srnec Novak +2 more
doaj +1 more source
Phenomenological Modelling of Cyclic Plasticity [PDF]
, 2012 The stress-strain behaviour of metals under a cyclic loading is very miscellaneous and needs an individual approach for different metallic materials. There are many different models that have been developed for the case of cyclic plasticity. This chapter will address only so called phenomenological models, which are based purely on the observed ...
Radim Halama, Josef Sedlk, Michal ofer
openaire +1 more source
Micro-mechanical modelling of high cycle fatigue behaviour of metals under multiaxial loads [PDF]
, 2012 An analysis of high cycle multiaxial fatigue behaviour is conducted through the numerical simulation of polycrystalline aggregates using the finite elementmethod.
PALIN-LUC, Thierry +3 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2017 This paper presents a finite strain elastoplastic constitutive model incorporating the extended subloading surface concept within the unconventional plasticity framework for cyclic loadings. This is a reformulated and extended version of the small strain
Takuya IGUCHI +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2013 It is important to be able to calculate the ratchet limit of a component when performing integrity assessments of plant components. This paper details the addition of a lower bound ratchet limit calculation to the Linear Matching Method. The extension of
Tipping, David +2 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Measurement and simulation of strain fields around crack tips under mixed-mode fatigue loading [PDF]
Fracture and Structural Integrity, 2015 For various configurations examined in a series of fatigue experiments on thin-walled tubes under tension and torsion, the experimental results – crack path, crack growth life, near crack tip deformations, and crack closure – are measured and compared to
Y. Hos, M. Vormwald, J.L.F. Freire
doaj +2 more sources