Results 61 to 70 of about 126,861 (303)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Extended subloading surface model based on multiplicative finite strain elastoplasticity framework: constitutive formulation and fully implicit return-mapping scheme

Nihon Kikai Gakkai ronbunshu, 2017
This paper presents a finite strain elastoplastic constitutive model incorporating the extended subloading surface concept within the unconventional plasticity framework for cyclic loadings. This is a reformulated and extended version of the small strain
Takuya IGUCHI, Yuki YAMAKAWA, Koichi HASHIGUCHI, Kiyohiro IKEDA   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Linear matching method for design limits in plasticity [PDF]

, 2010
In this paper a state-of-the-art numerical method is discussed for the evaluation of the shakedown and ratchet limits for an elastic-perfectly plastic body subjected to cyclic thermal and mechanical load history. The limit load or collapse load, i.e. the
Chen, Haofeng
core  

Experimental study on the cyclic resistance of a natural loess from Northern France [PDF]

, 2009
In order to analyze the instability phenomenon observed along the Northern High Speed Line of R\'eseau Ferr\'e de France (RFF), soil blocks were taken at a site near the railway, at four different depths (1.2, 2.2, 3.5 and 4.9 m).
Cui, Yu-Jun, Karam, Jean-Paul, Marchadier, Gilles, Tang, Anh-Minh, Terpereau, Jean-Marc   +4 more
core   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Creep fatigue life assessment of a pipe intersection with dissimilar material joint by linear matching method [PDF]

, 2016
As the energy demand increases the power industry has to enhance both efficiency and environmental sustainability of power plants by increasing the operating temperature.
Barbera, Daniele, Chen, Hao Feng, Liu, Ying Hua   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Experimental Study of Awash Soil under Static and Cyclic Shear Loading

Advances in Civil Engineering, 2023
The dynamic soil properties (shear modulus and damping ratio) are of great importance for the analysis and design of geotechnical structures subjected to dynamic loads such as earthquake. Cyclic simple shear tests were conducted to study the variation of
Tigistu Abu Arficho, Argaw Asha Ashango
doaj   +1 more source

Nonlinear modeling of the cyclic response of RC columns [PDF]

, 2012
Cyclic load reversals (like those induced by earthquakes) result in accelerated bond degradation, leading to significant bar slippage. The bond-slip mechanism is reported to be one of the most common causes of damage and even collapse of existing RC ...
Costa, A., Fernandes, C., Melo, J., Rossetto, T., Varum, H.   +4 more
core   +1 more source