Results 81 to 90 of about 46,614 (307)
Linear matching method for design limits in plasticity
, 2010 In this paper a state-of-the-art numerical method is discussed for the evaluation of the shakedown and ratchet limits for an elastic-perfectly plastic body subjected to cyclic thermal and mechanical load history. The limit load or collapse load, i.e. the
Chen, Haofeng
core
On the ratchet analysis of a cracked welded pipe [PDF]
, 2011 This paper presents the ratchet limit analysis of a pipe with a symmetric crack in a mismatched weld by using the extended Linear Matching Method (LMM). Two loading conditions are considered: i) a cyclic temperature load and a constant internal pressure;
Ure, James Michael +7 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Structural integrity assessment of superheater outlet penetration tubeplate
, 2009 In recent years, the Linear Matching Method (LMM) has been well developed for the integrity assessment of the component subjected to cyclic thermal and mechanical loads.
Haofeng Chen +3 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Cyclic Plasticity and Low Cycle Fatigue of an AISI 316L Stainless Steel: Experimental Evaluation of Material Parameters for Durability Design. [PDF]
Materials (Basel), 2021 Pelegatti M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Endothelial Plasticity: Shifting Phenotypes through Force Feedback
Stem Cells International, 2016 The endothelial lining of the vasculature is exposed to a large variety of biochemical and hemodynamic stimuli with different gradients throughout the vascular network.
Guido Krenning +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Strain Space Plasticity Model for Cyclic Mobility
Soils and Foundations, 1992 ABSTRACT The cyclic mobility model proposed in this paper is of a generalized plasticity—multiple mechanism type. The salient feature of the present approach is that the concept of the multiple mechanism, within the framework of plasticity theory defined in strain space, is used as a vehicle for decomposing the complex mechanism into a set of one ...
IAI, SUSUMU +2 more
openaire +2 more sources