Results 51 to 60 of about 126,861 (303)

Measurement and simulation of strain fields around crack tips under mixed-mode fatigue loading [PDF]

Fracture and Structural Integrity, 2015
For various configurations examined in a series of fatigue experiments on thin-walled tubes under tension and torsion, the experimental results – crack path, crack growth life, near crack tip deformations, and crack closure – are measured and compared to
Y. Hos, M. Vormwald, J.L.F. Freire
doaj   +2 more sources

Modelling of the behaviour of a welded joint subjected to reverse bending moment at high temperature [PDF]

, 2007
The paper is concerned with the modeling of the behaviour of welds when subjected to severe thermal and mechanical loads where the maximum temperature during dwell periods lies in the creep range.
Chen, Haofeng, Ponter, Alan R.S.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Influence of gaseous hydrogen on plastic strain in vicinity of fatigue crack tip in Armco pure iron

MATEC Web of Conferences, 2018
A multi-scale characterisation of the crack tip plasticity has been investigated in a fatigue crack propagation under gaseous hydrogen at gas pressure of 35 MPa in a commercially pure iron, Armco iron. The dislocation structure beneath a fracture surface
Shinko Tomoki, Hénaff Gilbert, Halm Damien, Benoit Guillaume   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Complexity without chaos: Plasticity within random recurrent networks generates robust timing and motor control [PDF]

, 2012
It is widely accepted that the complex dynamics characteristic of recurrent neural circuits contributes in a fundamental manner to brain function. Progress has been slow in understanding and exploiting the computational power of recurrent dynamics for ...
A Banerjee, A Litwin-Kumar, C Miall, C van Vreeswijk, CA Skarda, CV Buhusi, D Bueti, D Durstewitz, D Durstewitz, D Sussillo, DA Crowe, Dean V Buonomano, DJ Watts, DV Buonomano, DV Buonomano, DV Buonomano, DV Buonomano, DV Buonomano, E Pastalkova, EM Izhikevich, G Boffetta, G Fagiolo, H Jaeger, H Jaeger, H Kantz, H Merchant, H Sompolinsky, J Coull, JF Medina, JF Medina, JJ Hopfield, JK Liu, JX Li, K Rajan, M London, M Monteforte, M Rabinovich, MA Long, MB Ahrens, MD Mauk, MM Churchland, MS Goldman, MS Matell, N Brunel, P Janssen, P Simen, RB Ivry, RB Ivry, RHR Hahnloser, RM Church, Rodrigo Laje, S Ganguli, S Song, XJ Wang   +53 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Numerical implementation of a multiaxial cyclic plasticity model for the Local Strain Method in low cycle fatigue

Fracture and Structural Integrity, 2014
Very often computations on structural elements or machine components subjected to variable loading require using an advanced finite element model. This paper reports the numerical implementation of a model for multiaxial cyclic elasticplastic behaviour ...
C. Madrigal, V. Chaves, A. Navarro
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Cyclic J integral using linear matching method [PDF]

, 2012
The extended version of the latest Linear Matching Method (LMM) has the capability to evaluate the stable cyclic response, which produces cyclic stresses, residual stresses and plastic strain ranges for the low cycle fatigue assessment with cyclic load ...
Chen, Haofeng, Chen, Weihang
core