Influence of gaseous hydrogen on plastic strain in vicinity of fatigue crack tip in Armco pure iron
MATEC Web of Conferences, 2018 A multi-scale characterisation of the crack tip plasticity has been investigated in a fatigue crack propagation under gaseous hydrogen at gas pressure of 35 MPa in a commercially pure iron, Armco iron. The dislocation structure beneath a fracture surface
Shinko Tomoki +3 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Fracture and Structural Integrity, 2014 Very often computations on structural elements or machine components subjected to variable loading require using an advanced finite element model. This paper reports the numerical implementation of a model for multiaxial cyclic elasticplastic behaviour ...
C. Madrigal, V. Chaves, A. Navarro
doaj
Integrating the Chaboche Hardening Model into Phase Field Frameworks: A Numerical Study of Fatigue Crack Growth in S275 Mild Steel [PDF]
MATEC Web of ConferencesIn this research work, we present an implementation of the Chaboche hardening law within a phase field model to predict fatigue crack growth under cyclic plasticity in metals.
Zayani Iheb, Hamdi Adel, Mansouri Khalil
doaj +1 more source
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]
, 2012 Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J. +102 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Finite deformation of particulate geomaterials: frictional and anisotropic Critical State elasto-plasticity [PDF]
, 2011 This thesis is concerned with the theoretical development and numerical implementation of efficient constitutive models for the analysis of particulate media (specifically clays) in structures undergoing geometrically non-linear behaviour.
Coombs, W.M. +2 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A new accelerated technique for validation of cyclic plasticity models
MATEC Web of Conferences, 2018 This contribution presents a new methodology of fatigue tests evaluation based on digital image correlation application. The full-field strain analysis brings the possibility of 3D strain measurement evaluation on a curved part of specimen standardly ...
Halama Radim +3 more
doaj +1 more source