Results 91 to 100 of about 330,923 (308)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Study on the Effect of Cyclic Loading on the Geomechanics of Sandstone Reservoirs in Gas Storage

International Journal of Chemical Engineering
In the implementation process of carbon capture and storage (CCS), the geomechanical problems arising from the cyclic injection of carbon dioxide into the formation cannot be ignored.
Zhao Xiaolong, Zhao Yizhong, Wang Dongying, Zhao Zhuyu, Deng Yue, Yan Chuanliang, Chen Gang, Liang Wei, Lv Zehao   +8 more
doaj   +1 more source

A fully implicit multi-axial solution strategy for direct ratchet boundary evaluation : implementation and comparison [PDF]

, 2012
Ensuring sufficient safety against ratcheting is a fundamental requirement in pressure vessel design. However, determining the ratchet boundary using a full elastic plastic finite element analysis can be problematic and a number of direct methods have ...
Chen, Haofeng, Jappy, Alan, Mackenzie, Donald   +2 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Effect of proof testing on the flaw growth characteristics of 304 stainless steel [PDF]

The effects of proof overload frequency and magnitude on the cyclic crack growth rates of 304 stainless steel weldments were investigated. The welding procedure employed was typical of those used on over-the-road cryogenic vessels.
Finger, R. W.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Equivalent stress concept to account for the effect of local cyclic stress ratio on transverse cracking in tension–tension fatigue

International Journal of Fatigue
Presented test results on transverse cracking in cross-ply laminates upon tension–tension cyclic loading show that the increase of crack density depends not only on the maximum transverse stress in the cycle but also on the local cyclic stress ratio RTloc in the analyzed layer.
Vivek Richards Pakkam Gabriel, Mohamed Sahbi Loukil, Patrik Fernberg, Janis Varna   +3 more
openaire   +3 more sources

Effect of Cyclic Stress Level and Overconsolidation Ratio on Permanent Deformation Behaviour of Clayey Subsoil [PDF]

Civil Engineering Journal, 2018
This paper presents the results of a series of one-way cyclic triaxial tests carried out to investigate the role of cyclic stress level and overconsolidation ratio (OCR) on the permanent deformation behaviour of saturated clayey subsoil during long-term cyclic loading.
openaire   +1 more source

Prolonging thermal barrier coated specimen life by thermal cycle management [PDF]

Measurements were made of the rate of increase in temperature of a ZrO2-8Y2O3 thermal barrier coated (TBC) specimen for various values of fuel/air (F/A) ratios when the specimen is exposed to a 0.3 Mach burner flame.
Hendricks, R. C., Mcdonald, G., Poolos, N. P.   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source