Results 111 to 120 of about 71,348 (303)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Reação de substituição nucleofílica aromática em 1,2-dicloro-4,5-dinitrobenzeno [PDF]
, 2006 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Fisicas e Matematicas. Programa de Pós-Graduação em QuímicaO 1,2-dicloro-4,5-dinitrobenzeno (DCDNB) reage com aminas primárias e secundárias, em acetonitrila, em ...
Menezes, Fabrício Gava
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Anthanthrene dye-sensitized solar cells: influence of the number of anchoring groups and substitution motif [PDF]
, 2015 Four new dye molecules comprising an anthanthrene core, thiophene-cyanoacrylic acid electron acceptor and triphenylamine (TPA) electron donor units were prepared.
Yi, Chenyi +7 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Nature CommunicationsWhile copper-catalyzed asymmetric propargylic substitution has emerged as a versatile tool for constructing chiral propargylic frameworks, its application in forging cyclic chiral quaternary carbon centers remains a significant synthetic challenge.
Lili Shao +5 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Counter-cyclical substitution between trade credit and bank credit [PDF]
This paper explores the substitution relationship between trade credit and bank credit, and its counter-cyclic dynamic pattern through economic cycles. We propose a new theoretical model, using a mechanism design method, which predicts the substitution ...
Huang, Hui +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
REACTIONS OF CYCLIC OXIDES UNDER BIFUNCTIONAL HETEROGENEOUS ACID-BASE CATALYSIS
Cifra: ХимияThe reactions of cyclic epoxides form the basis for many industrial chemical technology processes. Unlike simple ethers, oxiranes tend to undergo nucleophilic cleavage reactions. The chemical properties of cyclic alkanes are primarily determined by their
Butenko E. +2 more
doaj +1 more source