Understanding the mechanism of Pd-catalyzed allylic substitution of the cyclic difluorinated carbonates [PDF]
Beilstein Journal of Organic Chemistry, 2008 We present a mechanistic investigation of Pd-catalyzed allylic substitution of cyclic gem-difluorinated carbonates 1 and 4, previously employed in the synthesis of 3',3'-difluoro-2'-hydroxymethyl-4',5'-unsaturated carbocyclic nucleosides in 17 steps. The
Jun Xu, Xiao-Long Qiu, Feng-Ling Qing
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Aryl substitution of pentacenes [PDF]
Beilstein Journal of Organic Chemistry, 2014 A series of 11 new pentacene derivatives has been synthesized, with unsymmetrical substitution based on a trialkylsilylethynyl group at the 6-position and various aryl groups appended to the 13-position.
Andreas R. Waterloo +4 more
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Synthesis and Characterization of New Cyclic Aminobenzoquinones [PDF]
Journal of the Turkish Chemical Society, Section A: Chemistry, 2018 The aim of this research is to synthesize and characterize of new cyclic members of cyclic aminobenzoquinones. Mono amino substituted products; 2-chloro-5,6-dimethyl-3-(pyrrolidin-1-yl)-1,4-benzoquinone (2), 2-chloro-5,6-dimethyl-3-(piperidin-1-yl)-1,4 ...
Amaç Fatih Tuyun, Mahmut Yıldız
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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution [PDF]
, 2021 We established a method for synthesizing a free cyclic peptide library via peptide array synthesis to demonstrate the sequence activity of cyclic peptides.
Kazunori Shimizu (149471) +11 more
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Nucleophilic Substitution Reactions of Cyclic Thiosulfinates Are Accelerated by Hyperconjugative Interactions [PDF]
, 2019 Strain energy has been shown to promote the nucleophilic substitution reactions of cyclic disulfides, the reactivities of cyclic thiosulfinate nucleophilic substitution is unexplored.
Daniel, Donnelly +2 more
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Nucleophilic Substitution at the Guanidine Carbon Center via Guanidine Cyclic Diimide Activation [PDF]
, 2021 Despite the electron-deficient nature of the guanidine carbon centers, nucleophilic reactions at these sites have been underdeveloped because of the resonance stabilization of the guanidine group.
Taeyang An (9017420) +3 more
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Amide-to-Ester Substitution Improves Membrane Permeability of a Cyclic Peptide Without Altering Its Three-Dimensional Structure [PDF]
, 2020 Cyclic peptides are attractive molecules as inhibitors with high affinity and selectivity against intracellular protein-protein interactions (PPIs).
Chad, Townsend +7 more
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Dialkylboryl-Substituted Cyclic Disilenes Synthesized by Desilylation-Borylation of Trimethylsilyl-Substituted Disilenes [PDF]
Molecules, 2021 π-Electron systems of silicon have attracted attention because of their narrow HOMO-LUMO gap and high reactivity, but the structural diversity remains limited. Herein, new dialkylboryl-substituted disilenes were synthesized by the selective desilylation-borylation of the corresponding trimethylsilyl-substituted disilenes.
Kaho Tanaka +6 more
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Direct Regioselective Dehydrogenation of α‐Substituted Cyclic Ketones
Angewandte Chemie International Edition, 2023 AbstractWe disclose a highly regioselective, catalytic one‐step dehydrogenation of α‐substituted cyclic ketones in the presence of 2,3‐dichlorobenzo‐5,6‐dicyano‐1,4‐benzoquinone (DDQ). The high regioselectivity originates from a phosphoric acid‐catalyzed enolization, selectively affording the thermodynamically preferred enol, followed by the subsequent
Sebastian Armin Schwengers +8 more
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Hypervalent Iodine-Mediated Diastereoselective α-Acetoxylation of Cyclic Ketones
Frontiers in Chemistry, 2020 A binary hybrid system comprising a hypervalent iodine(III) reagent and BF3•OEt2 Lewis acid was found to be effective for the diastereoselective α-acetoxylation of cyclic ketones.
Jiashen Tan +8 more
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