Results 11 to 20 of about 904,141 (304)
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides [PDF]
Nature Communications, 2023 Naturally occurring peptides with high membrane permeability often have backbone ester bonds. Here, the authors investigated the effect of an amide-to-ester substitution on membrane permeability of peptides and found the substitution is useful for ...
Yuki Hosono +16 more
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Beilstein Journal of Organic Chemistry, 2008 We present a mechanistic investigation of Pd-catalyzed allylic substitution of cyclic gem-difluorinated carbonates 1 and 4, previously employed in the synthesis of 3',3'-difluoro-2'-hydroxymethyl-4',5'-unsaturated carbocyclic nucleosides in 17 steps. The
Jun Xu, Xiao-Long Qiu, Feng-Ling Qing
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A Natural Approach to Solving the Traveling Salesman Problem
Кібернетика та комп'ютерні технології, 2023 Introduction. The traveling salesman problem is a transport-type problem. It is natural to use a method based on the technology for solving transport problems to solve it.
Dmitri Terzi
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Error correction by Reed–Solomon codes using its automorphisms
Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2021 The article explores the syndrome invariants of АГ-group of automorphisms of Reed–Solomon codes (RS-codes) that are a joint group of affine and cyclic permutations. The found real invariants are a set of norms of N Г-orbits that make up one or another АГ-
V. A. Lipnitsky, S. I. Semyonov
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Three-Component Condensation of β-Ketonitriles, 4-Fluorobenzaldehyde, and Secondary Cyclic Amines
Reactions, 2022 A new three-component condensation of β-ketonitriles, 4-fluorobenzaldehyde, and secondary cyclic amines was developed. A possible reaction mechanism has been proposed including Knoevenagel condensation followed by aromatic nucleophilic substitution.
Dmitry V. Osipov +2 more
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Nucleophilic Substitution Reactions of Cyclic Thiosulfinates Are Accelerated by Hyperconjugative Interactions [PDF]
, 2019 Strain energy has been shown to promote the nucleophilic substitution reactions of cyclic disulfides, the reactivities of cyclic thiosulfinate nucleophilic substitution is unexplored.
Daniel, Donnelly +2 more
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The automorphisms and error orbits of Reed – Solomon codes
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2020 The purpose of this work with its results presented in the article was to develop and transfer to the class of Reed – Solomon codes (RS-codes) the basic provisions of the theory of syndrome norms (TNS), previously developed for the noise-resistant coding
S. I. Semyonov, V. A. Lipnitsky
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Amide-to-Ester Substitution Improves Membrane Permeability of a Cyclic Peptide Without Altering Its Three-Dimensional Structure [PDF]
, 2020 Cyclic peptides are attractive molecules as inhibitors with high affinity and selectivity against intracellular protein-protein interactions (PPIs).
Chad, Townsend +7 more
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Syndrome spectrums of error orbits in RS-codes
Системный анализ и прикладная информатика, 2020 This article is devoted to the research of the properties of syndromes of errors in Reed-Solomon codes. RS-codes are built on non-binary alphabets. So, unlike BCH-codes, RS-codes contain an extremely large variety of correctable errors.
V. A. Lipnitski, S. I. Semyonov
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Безопасность информационных технологий, 2021 The paper investigates a nonlinear substitution transformation, presented as an element of the number system of factorial sets. This approach takes into account the characteristic features of substitutions and al-lows you to minimize the amount of memory
Alexander P. Martynov +2 more
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