Results 31 to 40 of about 71,348 (303)

Impact of Peptide Structure on Colonic Stability and Tissue Permeability

Pharmaceutics, 2023
Most marketed peptide drugs are administered parenterally due to their inherent gastrointestinal (GI) instability and poor permeability across the GI epithelium.
Farhan Taherali, Nerisha Chouhan, Fanjin Wang, Sebastien Lavielle, Maryana Baran, Laura E. McCoubrey, Abdul W. Basit, Vipul Yadav   +7 more
doaj   +1 more source

α-Bromodiazoacetamides – a new class of diazo compounds for catalyst-free, ambient temperature intramolecular C–H insertion reactions

Beilstein Journal of Organic Chemistry, 2013
In this work, we introduce a new class of halodiazocarbonyl compounds, α-halodiazoacetamides, which through a metal-free, ambient-temperature thermolysis perform intramolecular C–H insertions to produce α-halo-β-lactams.
Åsmund Kaupang, Tore Bonge-Hansen
doaj   +1 more source

Diels-Alder reactions as an efficient route to high purity cyclic polymers [PDF]

, 2011
A simple and efficient route for the synthesis of cyclic polymer systems is presented. Linear furan protected α-maleimide-ω-cyclopentadienyl functionalized precursors (poly(methyl methacrylate) and poly(tert-butyl acrylate)) were synthesized via atom ...
James P. Blinco, Christopher Barner-Kowollik, Blinco, James P., Glassner, Mathias, Barner-Kowollik, Christopher, Mathias Glassner   +5 more
core   +1 more source

Predicting B cell receptor substitution profiles using public repertoire data. [PDF]

PLoS Computational Biology, 2018
B cells develop high affinity receptors during the course of affinity maturation, a cyclic process of mutation and selection. At the end of affinity maturation, a number of cells sharing the same ancestor (i.e.
Amrit Dhar, Kristian Davidsen, Frederick A Matsen, Vladimir N Minin   +3 more
doaj   +1 more source

Approach to the Synthesis of Five-Membered Organophosphorus Compounds via Alumoles and Alumolanes

Chemistry Proceedings, 2022
This work summarizes the results of a new approach to the synthesis of previously undescribed, hard-to-obtain five-membered cyclic organophosphorus compounds: 3-alkyl(aryl)-substituted phospholanes, α,ω-bisphospholanes, polycyclic phospholanes, 4,5 ...
Alevtina L. Makhamatkhanova, Tatyana V. Tyumkina, Usein M. Dzhemilev   +2 more
doaj   +1 more source

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Haastert, Peter J.M. van,, Kesbeke, Fanja, Kesbeke, Fanja,, Haastert, Peter J.M. van, Janina Baraniak, Baraniak, Janina,, Bulgakov, Roman,, Seela, Frank,, Roman Bulgakov, Stec, Wojciech J.,, Bernd Jastorff, Fanja Kesbeke, Gcorg Petridis, Petridis, Georg, Morr, Michael,, Jastorff, Bernd, Jastorff, Bernd,, Morr, Michael, Petridis, Georg,, Baraniak, Janina, Seela, Frank, Bulgakov, Roman, Michael Morr, Frank Seela, Stec, Wojciech J., Wojcicch J. Stec   +25 more
core   +1 more source

Enhancing thermodynamic stability of single-crystal Ni-rich cathode material via a synergistic dual-substitution strategy [PDF]

, 2023
Nickel (Ni)-rich cathode materials have become promising candidates for the next-generation electrical vehicles due to their high specific capacity. However, the poor thermodynamic stability (including cyclic performance and safety performance or thermal
Jixue Shen, Chuanbo Zheng, Du, Weitong, Hao Chen, Weitong Du, Shanqing Zhang, Zhang, Shanqing, Li, Hui, Qi, Haoyu, Zeheng Li, Zhan Lin, Shen, Jixue, Hui Li, Lin, Zhan, Li, Zeheng, Zheng, Chuanbo, Chen, Hao, Haoyu Qi   +17 more
core   +1 more source

Amphiphilic Polyfluorinated Amino Ethers from Cyclic Sulfamidates [PDF]

, 2022
Regioselective ring opening of cyclic sulfamidates was achieved by means of nucleophilic polyfluorinated alkoxides to access achiral and chiral β- and γ-ORF amines and α-amino esters.
Jun-An Ma, Jun-An Ma (1393726), Nicolas Marie, Ma, Jun-An, Dominique Cahard (1617196), Cahard, Dominique, Dominique Cahard, Marie, Nicolas, Nicolas Marie (335112)   +8 more
core   +1 more source

MODIFICATION OF THE ENERGY-SATURATED HETEROGENEOUS COMPOSITE MATERIAL BY CYCLIC NITRAMINES

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2018
Several methods have been described for increasing the main characteristics (density, heat of combustion, combustion temperature, gas formation index) and operating properties (combustion speed and temperature, total and specific impulse, properties of ...
A. Ph. Ilyushchanka, Ya. Ya. Piatsiushyk, A. K. Kryvanos   +2 more
doaj   +1 more source

Cyclic behaviour of Volterra composition operators [PDF]

, 2011
We determine the cyclic behaviour of Volterra composition operators, which are defined as $(V_\phif)(x) =\int_0^{\phi(x)}f(t) dt$, $f ? L^p[0, 1]$, 1\leq p <\infty$,where $?$ is a measurable self-map of [0, 1].
Stanislav Shkarin, Alfonso Montes-Rodríguez, Rodriguez-Martinez, Alejandro, Montes-Rodriguez, A., Alejandro Rodríguez-Martínez, Shkarin, Stanislav   +5 more
core   +1 more source