Results 51 to 60 of about 904,141 (304)
International Journal of Electrochemical Science, 2017 La-based Perovskite-type oxides with composition La1-xCuxCoO3 (0 ≤ X ≤ 0.8) have been synthesized by malic acid sol-gel low temperature route at pH 3.75.
N.K. Singh, M.K. Yadav, Carlos Fernandez
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Cell Reports, 2014 The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials. DMXAA was later discovered to activate mouse, but not human, STING, an adaptor protein
Pu Gao +9 more
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Molecules, 2023 Substituent-regulated cyclization of conjugated alkynes with acid catalysis was developed in this paper, and it provides a straightforward synthesis of cyclic-(E)-[3]dendralenes.
Yun-Tao Xia +6 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Selenium halide-induced bridge formation in [2.2]paracyclophanes
Beilstein Journal of Organic Chemistry, 2014 An addition/elimination sequence of selenium halides to pseudo-geminally bis(acetylene) substituted [2.2]paracyclophanes leads to new bridges with an endo-exo-diene substructure.
Laura G. Sarbu +3 more
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Direct Regioselective Dehydrogenation of α‐Substituted Cyclic Ketones
Angewandte Chemie International Edition, 2023 AbstractWe disclose a highly regioselective, catalytic one‐step dehydrogenation of α‐substituted cyclic ketones in the presence of 2,3‐dichlorobenzo‐5,6‐dicyano‐1,4‐benzoquinone (DDQ). The high regioselectivity originates from a phosphoric acid‐catalyzed enolization, selectively affording the thermodynamically preferred enol, followed by the subsequent
Sebastian Armin Schwengers +8 more
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
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Constitutive modelling of the behaviour of clays under cyclic loading [PDF]
, 1989 Includes bibliography.This research work involved the implementation of a constitutive model based on plasticity theory to model the behaviour of a clay under cyclic loading.
Sellers, E J
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