Results 61 to 70 of about 71,348 (303)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Substitution Reactions in Aromatic Systems [PDF]
, 1968 Quantitative aspects of recent developments in theories of electrophilic aromatic substitution are reviewed, and it is shown how better understanding of these theories can help to predict with greater accuracy, optimum conditions for maximum yield of a ...
Taylor, R., R. Taylor
core +2 more sources
Modulation of Antibacterial Activity and Cytotoxicity in Amphipathic Cyclic Peptide [R4W4] Using Histidine Substitution [PDF]
, 2021 Antibiotics have been the gold standard frontline defense against bacterial infections for decades. At the same time, these infecting bacteria have continued to evolve to resist developed antibiotics in an almost endless cycle. As such, we aim to take an
Stueber, Ryan
core +2 more sources
Tandem Ring Opening−Ring Closing Metathesis of Cyclic Olefins [PDF]
, 2016 Ruthenium alkylidene 1 has been utilized in the tandem ring opening−ring closing metathesis of cyclic olefins. This reaction produces a bicyclic molecule from a cyclic olefin.
William J. Zuercher (13844) +2 more
core +3 more sources
Selenium halide-induced bridge formation in [2.2]paracyclophanes
Beilstein Journal of Organic Chemistry, 2014 An addition/elimination sequence of selenium halides to pseudo-geminally bis(acetylene) substituted [2.2]paracyclophanes leads to new bridges with an endo-exo-diene substructure.
Laura G. Sarbu +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Experimental and theoretical studies of the redox potentials of cyclic nitroxides [PDF]
, 2008 The redox potentials of 25 cyclic nitroxides from four different structural classes (pyrrolidine, piperidine, isoindoline, and azaphenalene) were determined experimentally by cyclic voltammetry in acetonitrile, and also via high-level ab initio molecular
Hodgson, Jennifer L. +6 more
core +1 more source
International Journal of Electrochemical Science, 2020 This paper deals the findings of quaternary perovskite-type oxides, La0.4SmxSr0.6-xCoO3 (0 ≤ x ≤ 0.4), which is the extended research work obtained by further substitution Sm (0.2 to 0.4 mol) for Sr in the ternary perovskite oxide of La0.4Sr0.6CoO3 ...
Narendra Kumar Singh +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source