Results 61 to 70 of about 171,446 (256)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Indirect verification of suction in cyclic UCS tests of a chemically stabilized soil [PDF]

open access: yesE3S Web of Conferences
The present study aims to indirectly evaluate the occurrence of suction and its effects in laboratory tests of a chemically stabilized soft soil. To achieve these goals, a series of unconfined compressive strength (UCS) and triaxial tests were performed,
Martins Ligia A.   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluation and Comparison of two Frequently Used Cyclic Constitutive Models for Sandy Soils [PDF]

open access: yesمدل‌سازی پیشرفته در مهندسی عمران
Selection of an appropriate soil constitutive model for advanced numerical analyses requires thorough understanding of behavior of constitutive models. Here, SANISAND and HS-SMALL models which are advanced widely available soil models for cyclic behavior
Hossein Javaheri Koupaei, Samad Choobi
doaj   +1 more source

Accelerated cyclic corrosion tests [PDF]

open access: yesKoroze a ochrana materialu, 2016
Abstract Accelerated corrosion testing is indispensable for material selection, quality control and both initial and residual life time prediction for bare and painted metallic, polymeric, adhesive and other materials in atmospheric exposure conditions. The best known Neutral Salt Spray (NSS) test provides unrealistic conditions and poor
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Evolution of the Damping Ratio Considering Cyclic Confining Pressure Under Intermittent Cyclic Loading

open access: yesBuildings
The damping ratio is essential to conducting dynamic analysis for underground engineering under traffic loading. Variations in the damping ratio are usually studied using cyclic triaxial tests with continuous cyclic loading; however, intermittent loading
Juehao Huang   +5 more
doaj   +1 more source

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