Results 321 to 330 of about 504,196 (405)

Influence of Epithelial-Mesenchymal Transition on Risk of Relapse and Outcome to Eribulin or Cyclin-Dependent Kinase Inhibitors in Metastatic Breast Cancer. [PDF]

JCO Precis Oncol
Chan A, Gill J, Chih H, Wright SCE, Vasilevski N, Eichhorn PJA.   +5 more
europepmc   +1 more source

PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma

Cancer Science, EarlyView.
PBK plays a crucial role in cell survival in mesothelioma and is associated with worse outcome. PBK is a promising therapeutic target that may serve as a prognostic biomarker, enabling personalized treatment of mesothelioma. ABSTRACT Mesothelioma is one of the most aggressive neoplasms worldwide that has a particularly poor prognosis.
Kazumi Hori, Ichidai Tanaka, Tatsuhiro Sato, Mika Sato, Yuta Kodama, Hideyuki Itoigawa, Yuichi Abe, Taketo Kato, Ayumu Taguchi, Mitsuo Sato, Yoshitaka Sekido, Toyofumi Fengshi Chen‐Yoshikawa, Makoto Ishii   +12 more
wiley   +1 more source

Associations of maternal cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(CDKAL1) gene variants with adverse pregnancy outcome in Chinese women. [PDF]

BMC Pregnancy Childbirth
Yue S, Su M, Zhang Z, Li J, Leng J, Li W, Liu J, Zhang T, Qiao Y, Yu Z, Hu G, Ma J, Yang X, Wang H.   +13 more
europepmc   +1 more source

MiR-192-5p targets cell cycle regulation in diabetic kidney disease via cyclin-dependent kinase inhibitor 3. [PDF]

Noncoding RNA Res
Sahoo B, Mishra DD, Tiwari S.
europepmc   +1 more source

Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target. [PDF]

Cells
Marschall M, Schütz M, Wild M, Socher E, Wangen C, Dhotre K, Rawlinson WD, Sticht H.   +7 more
europepmc   +1 more source

Anti colorectal cancer activity and in silico studies of novel pyridine nortopsentin analog as cyclin dependent kinase 6 inhibitor. [PDF]

Sci Rep
Abdelmegeed H, Abo-Salem HM, Zayed EM, El-Sawy ER.   +3 more
europepmc   +1 more source

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Cyclin-Dependent Kinases

Chemical Reviews, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. D. Adams, J. W. Harper
openaire   +6 more sources

Targets of the cyclin-dependent kinase Cdk1

Nature, 2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A. Ubersax, E. L. Woodbury, P. Quang, M. Paraz, J. Blethrow, K. Shah, K. Shokat, D. Morgan   +7 more
semanticscholar   +4 more sources

Cyclin-dependent kinase inhibitors.

Progress in cell cycle research, 2003
Cyclin-dependent kinases are involved in diverse cellular processes that include cell cycle control, apoptosis, neuronal physiology, differentiation, and transcription. Intensive screening and drug design based on CDK/inhibitor co-crystal structures and on SAR studies have led to the identification and characterization of a large variety of chemical ...
P. M., Fischer, Endicott, J., Meijer, L.
openaire   +6 more sources

Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.

Journal of Medicinal Chemistry, 2018
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types. Although
S. Tadesse, E. Caldon, W. Tilley, Shudong Wang   +3 more
semanticscholar   +1 more source