Results 321 to 330 of about 386,039 (382)

Cyclin-dependent kinase pathways as targets for cancer treatment.

Journal of Clinical Oncology, 2006
Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic and epigenetic events cause universal overactivity of the cell cycle cdks in human cancer, and their inhibition can lead to both
G. Shapiro
semanticscholar   +1 more source

Identification of substrates for cyclin dependent kinases

Advances in Enzyme Regulation, 2010
Protein phosphorylation is a key regulatory mechanism for cell cycle control in eukaryotes. From yeast to humans, cell cycle progression and cell division require the activation of a group of serine– threonine protein kinases called cyclin dependent kinases (CDKs) (Morgan, 1997), which initiate and coordinate these processes by orderly phosphorylation ...
Krupa Deshmukh, Andrei Pozniakovsky, Yoshimi Tanaka, Tim Hunt, Alessia Errico   +4 more
openaire   +3 more sources

Pharmacological inhibitors of cyclin-dependent kinases

Trends in Pharmacological Sciences, 2002
Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. Deregulation of CDKs in various diseases has stimulated an intensive search for selective pharmacological inhibitors of these kinases.
Marie Knockaert, Paul Greengard, Laurent Meijer   +2 more
openaire   +3 more sources

Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Mini-Reviews in Medicinal Chemistry, 2012
Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
Shreyans K. Jain, Sandip B. Bharate, Ram A. Vishwakarma   +2 more
openaire   +3 more sources

Chemical inhibitors of cyclin-dependent kinases

Trends in Cell Biology, 1995
The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
openaire   +5 more sources

Quinazolines as cyclin dependent kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2001
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
Haiying Chen, Jie Liu, Jodi K. Muckelbauer, Steven P. Seitz, Pamela A. Benfield, Sarah Cox, John F. Boylan, Tricia L. Johnson, Chong-Hwan Chang, Catherine R. Burton, Robert H. Grafstrom, Angela Smallwood, Michael D. Boisclair, Thais M. Sielecki, George L. Trainor   +14 more
openaire   +3 more sources

p27KIP1, an inhibitor of cyclin-dependent kinases

1995
The identification of a family of proteins that stoichiometrically regulate the activation of the G1 cyclin-dependent kinases has added to our understanding of the process of commitment to the mitotic cycle. The properties of p27 as a CDK binding protein, the ability of environmental signals to regulate the expression of p27, and the observation that ...
Kornelia Polyak, Andrew Koff
openaire   +3 more sources

Cyclins, cyclin‐dependent kinases and differentiation

BioEssays, 1997
AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
Chun Y. Gao, Peggy S. Zelenka
openaire   +3 more sources

Functional Evolution of Cyclin-Dependent Kinases

Molecular Biotechnology, 2009
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases with a well established role in the regulation of the eukaryotic cell cycle. Recent studies with animal cells have implicated CDK activity in additional diverse cellular processes, including transcription, translation and mRNA processing.
John H. Doonan, Georgios Kitsios
openaire   +3 more sources

Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity

Journal of Medicinal Chemistry, 2006
Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 mutants bearing equivalent cyclin-dependent kinase 4 residues,
Pratt DJ, Bentley J, Jewsbury P, Boyle FT, Endicott JA, Noble MEM   +5 more
openaire   +4 more sources