Results 331 to 340 of about 386,039 (382)

Cyclin-dependent kinases as targets for cancer therapy

Update on Cancer Therapeutics, 2003
Cell cycle perturbations are commonly observed in human malignancies. Exploiting this finding is the rationale for the development of CDK inhibitors as anti-tumor agents. Single-agent evaluation of several CDKIs has demonstrated limited clinical activity.
Gary K. Schwartz, Manish A. Shah
openaire   +5 more sources

Targets of cyclin-dependent protein kinases

Current Opinion in Cell Biology, 1993
Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression.
openaire   +3 more sources

Smad3 phosphorylation by cyclin-dependent kinases

Cytokine & Growth Factor Reviews, 2006
Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family members, Smad3 is the only CDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function.
openaire   +3 more sources

The dynamics of cyclin dependent kinase structure

Current Opinion in Cell Biology, 1996
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition ...
openaire   +3 more sources

Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Cell, 1994
K. Polyak, Mong-Hong Lee, H. Erdjument-Bromage, A. Koff, James M. Roberts, P. Tempst, J. Massagué   +6 more
semanticscholar   +1 more source

Measuring Cyclin-Dependent Kinase Activity

2004
The activity of cyclin-dependent kinases (CDKs) lies at the heart of cell cycle and checkpoint control. These complexes have been called the "cell cycle engine," as it is their enzymatic activity that pushes the cells through the cell-division cycle.
openaire   +3 more sources

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.

Pharmacological Research, 2019
R. Roskoski
semanticscholar   +1 more source

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

Nature, 1994
T. Nobori, K. Miura, David J. Wu, A. Lois, K. Takabayashi, D. Carson   +5 more
semanticscholar   +1 more source

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.

Bioorganic & Medicinal Chemistry Letters, 2015
Concha Sánchez-Martínez, L. Gelbert, M. Lallena, A. de Dios   +3 more
semanticscholar   +1 more source

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Cell, 1994
V. Dulić, W. Kaufmann, Sandra J. Wilson, Thea D. Tisty, E. Lees, J. Harper, S. Elledge, S. Reed   +7 more
semanticscholar   +1 more source